Talikoti Prashanth, Bobby Zachariah, Hamide Abdoul
Biochemistry, Employees' State Insurance Corporation (ESIC) Medical College, Gulbarga, IND.
Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, IND.
Cureus. 2023 Jan 7;15(1):e33481. doi: 10.7759/cureus.33481. eCollection 2023 Jan.
Prehypertensives are at higher risk of developing cardiovascular diseases. Hyperhomocysteinemia, insulin resistance, and increased high-sensitivity C-reactive protein (hs-CRP) are independent risk factors for the development of cardiovascular complications. In prehypertensives, specific therapeutic approaches can be implemented at the earliest to prevent the onset of overt hypertension. So the present study was performed to study the effect of supplementation of water-soluble vitamins on cardiovascular risk factors like homocysteine, insulin resistance, and C-reactive protein in prehypertensive subjects.
Sixty prehypertensive subjects were recruited into the study based on inclusion and exclusion criteria and randomized into two groups of 30 each. One group was given a placebo and the other was given water-soluble vitamins for four months. Serum homocysteine, insulin, homeostatic model assessment of insulin resistance (HOMA-IR), and hs-CRP were assayed.
After four months of treatment with water-soluble vitamins, there was a significant decrease in levels of serum homocysteine, hs-CRP, and HOMA-IR when compared to placebo treatment. After four months of treatment, there was a significant decrease in the levels of hs-CRP, homocysteine, and HOMA-IR in groups treated with water-soluble vitamins compared to the basal levels.
In subjects with prehypertension, supplementation of water-soluble vitamins decreases the level of homocysteine, insulin resistance, and hs-CRP.
血压正常高值者患心血管疾病的风险更高。高同型半胱氨酸血症、胰岛素抵抗以及高敏C反应蛋白（hs-CRP）升高是心血管并发症发生的独立危险因素。对于血压正常高值者，可尽早采取特定治疗方法以预防显性高血压的发生。因此，本研究旨在探讨补充水溶性维生素对血压正常高值者同型半胱氨酸、胰岛素抵抗及C反应蛋白等心血管危险因素的影响。
根据纳入和排除标准，招募60名血压正常高值者进入研究，并随机分为两组，每组30人。一组给予安慰剂，另一组给予水溶性维生素，为期四个月。检测血清同型半胱氨酸、胰岛素、胰岛素抵抗稳态模型评估（HOMA-IR）及hs-CRP。
与安慰剂治疗相比，水溶性维生素治疗四个月后，血清同型半胱氨酸、hs-CRP及HOMA-IR水平显著降低。治疗四个月后，与基础水平相比，接受水溶性维生素治疗组的hs-CRP、同型半胱氨酸及HOMA-IR水平显著降低。
在血压正常高值者中，补充水溶性维生素可降低同型半胱氨酸水平、胰岛素抵抗及hs-CRP。
