Liu Zhiwei, Zhang Yulong, Wang Juan, Xia Lei, Yang Yating, Sun Liang, Zhang Dapeng, Li Wenzheng, Yao Xianhu, Yang Rongchun, Liu Yun, Liu Huanzhong
Department of Psychiatry, The Third People's Hospital of Fuyang, Fuyang, China.
Department of Psychiatry, Chaohu Hospital of Anhui Medical University, Chaohu, China.
Front Psychiatry. 2022 Aug 25;13:992988. doi: 10.3389/fpsyt.2022.992988. eCollection 2022.
Previous research has revealed that plasma leptin levels were closely related to glycolipid metabolism in schizophrenic patients. Insulin resistance (IR) and high sensitivity C-reactive protein (hs-CRP) were involved in glucolipid metabolism disorders. This study explored the correlation between plasma higher leptin levels, homeostasis model assessment of insulin resistance (HOMA-IR) index, hs-CRP and glycolipid metabolism in patients with chronic schizophrenia (CS).
322 subjects were enrolled, and the psychopathological symptoms of each patient were assessed by a 30-item Positive and Negative Syndrome Scale (PANSS). Patients' plasma leptin levels were measured by enzyme-linked immunosorbent assay (ELISA). Fasting blood glucose (FBG) levels were determined by oxidase method. Insulin levels were tested by electrochemiluminescence, and hs-CRP levels were tested by immunoturbidimetry. was used for data analysis.
Compared to the lower leptin group, patients in the higher leptin group had significantly higher body mass index (BMI), total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL-C), insulin, HOMA-IR and hs-CRP levels; and lower negative factor scores, cognitive factor scores, and PANSS total scores ( < 0.05). Plasma leptin levels in CS patients were positively correlated with BMI, TC, TG, LDL-C, insulin, HOMA-IR and hs-CRP levels, and were negatively correlated with gender (male = 1, Female = 2), positive factor scores, negative factor scores, cognitive factor scores and PANSS total scores. Multiple linear regression analysis revealed that gender, BMI, positive factor scores, PANSS total scores, FBG, LDL-C, insulin, HOMA-IR and hs-CRP levels were independent influencing factors of leptin levels in CS patients ( < 0.05).
Gender, BMI, positive factor scores, PANSS total scores, FBG, LDL-C, insulin, HOMA-IR and hs-CRP levels were independent influencing factors of plasma leptin levels in CS patients. Plasma leptin, HOMA-IR and hs-CRP levels should be measured regularly in CS patients to prevent or treat the disorders of glucose and lipid metabolism comorbidity with schizophrenia patients in clinical diagnosis and treatment.
先前的研究表明，精神分裂症患者的血浆瘦素水平与糖脂代谢密切相关。胰岛素抵抗（IR）和高敏C反应蛋白（hs-CRP）参与了糖脂代谢紊乱。本研究探讨了慢性精神分裂症（CS）患者血浆中较高的瘦素水平、胰岛素抵抗稳态模型评估（HOMA-IR）指数、hs-CRP与糖脂代谢之间的相关性。
招募322名受试者，通过30项阳性和阴性症状量表（PANSS）评估每位患者的精神病理症状。采用酶联免疫吸附测定（ELISA）法检测患者血浆瘦素水平。采用氧化酶法测定空腹血糖（FBG）水平。采用电化学发光法检测胰岛素水平，采用免疫比浊法检测hs-CRP水平。 用于数据分析。
与低瘦素组相比，高瘦素组患者的体重指数（BMI）、总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白（LDL-C）、胰岛素、HOMA-IR和hs-CRP水平显著更高；阴性因子得分、认知因子得分和PANSS总分更低（<0.05）。CS患者血浆瘦素水平与BMI、TC、TG、LDL-C、胰岛素、HOMA-IR和hs-CRP水平呈正相关，与性别（男性=1，女性=2）、阳性因子得分、阴性因子得分、认知因子得分和PANSS总分呈负相关。多元线性回归分析显示，性别、BMI、阳性因子得分、PANSS总分、FBG、LDL-C、胰岛素、HOMA-IR和hs-CRP水平是CS患者瘦素水平的独立影响因素（<0.05）。
性别、BMI、阳性因子得分、PANSS总分、FBG、LDL-C、胰岛素、HOMA-IR和hs-CRP水平是CS患者血浆瘦素水平的独立影响因素。在临床诊断和治疗中，应定期检测CS患者的血浆瘦素、HOMA-IR和hs-CRP水平，以预防或治疗合并精神分裂症患者的糖脂代谢紊乱。
