Zdanowicz Katarzyna, Bobrus-Chociej Anna, Kopiczko Anna, Uścinowicz Mirosława, Tomczuk-Ostapczuk Monika, Janica Jacek, Łotowska Joanna Maria, Białokoz-Kalinowska Irena, Lebensztejn Dariusz Marek
Medical University of Bialystok, Bialystok, Poland.
Lomza State University of Applied Sciences, Lomza, Poland.
Cent Eur J Immunol. 2022;47(2):183-187. doi: 10.5114/ceji.2022.116368. Epub 2022 May 30.
The spectrum of liver involvement during coronavirus disease 2019 (COVID-19) is broad and mainly includes elevated liver enzymes and cholestasis. Severe acute respiratory syndrome corona- virus-2 (SARS-CoV-2) infection most often leads to a transient moderate increase in liver enzymes that is not accompanied by disturbances in the synthetic function of the liver. However, there is increasing evidence that SARS-CoV-2 infection is associated with the development of autoimmune disorders. The pathogenesis of autoimmune hepatobiliary diseases is not fully understood, taking into account genetic and environmental factors such as viral infections. We present a pediatric case of autoimmune sclerosing cholangitis (ASC), which was diagnosed 2 months after SARS-CoV-2 infection. To the best of our knowledge, ASC potentially triggered by COVID-19 has not been reported in pediatric patients. Further studies are needed to describe the clinical impact of the development of autoimmune liver diseases potentially associated with SARS-CoV-2 infection in pediatric patients. Our observations indicate that children with liver injury potentially caused by COVID-19 require long-term monitoring of liver function parameters.
2019年冠状病毒病（COVID-19）期间肝脏受累的范围广泛，主要包括肝酶升高和胆汁淤积。严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染最常导致肝酶短暂中度升高，且不伴有肝脏合成功能障碍。然而，越来越多的证据表明，SARS-CoV-2感染与自身免疫性疾病的发生有关。考虑到病毒感染等遗传和环境因素，自身免疫性肝胆疾病的发病机制尚未完全明确。我们报告1例儿童自身免疫性硬化性胆管炎（ASC）病例，该病例在SARS-CoV-2感染2个月后确诊。据我们所知，儿科患者中尚未报道由COVID-19潜在引发的ASC。需要进一步研究来描述自身免疫性肝病的发生对儿科患者的临床影响，这些自身免疫性肝病可能与SARS-CoV-2感染有关。我们的观察结果表明，可能由COVID-19导致肝损伤的儿童需要长期监测肝功能参数。
