Gameil Mohammed Ali, Marzouk Rehab Elsayed, Elsebaie Ahmed Hassan, Rozaik Salah Eldeen
Endocrinology Unit, Internal Medicine Department, Faculty of Medicine, Mansoura University, Mansoura, Dakahlia Egypt.
Medical Biochemistry Department, Faculty of Medicine, Mansoura University, Mansoura, Dakahlia Egypt.
Egypt Liver J. 2021;11(1):74. doi: 10.1186/s43066-021-00144-1. Epub 2021 Sep 12.
The long-term health consequences of coronavirus disease 2019 (COVID-19) are still unclear. The majority of previous trials addressed the post-COVID-19 symptoms through comprehensive medical questionnaires for relatively short periods after recovery. We tried to detect the potential pathological clinical signs and biochemical residue which persist for more than 3 months after the negative real-time polymerase chain reaction (RT-PCR) test of SARS-CoV-2.
Among 120 COVID-19 survivors of mean age 38.29 and 55.6% male proportion, systolic blood pressure was significantly elevated ( =0.001). Erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), D-dimer showed higher values in COVID-19 survivors ( < 0.001). Alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl trans-peptidase (GGT), and alkaline phosphatase (ALP) were significantly elevated in contrast to serum albumin that was reduced in COVID-19 survivors ( ≤0.001). Serum lipase, amylase and albuminuria were higher in COVID-19 survivors ( ≤0.001). Regression analysis (AOR, 95% CI) showed that ESR ( = 0.014), haemoglobin concentration ( = 0.039), serum lipase ( = 0.018), blood urea nitrogen ( = 0.003), albuminuria ( = 0.046), 25(OH) vitamin D ( = 0.002), and serum uric acid ( = 0.005) were the significant predictors of COVID-19 survivors (94.8% an overall prediction).
COVID-19 survivors experienced residual significant clinical and biochemical alterations that necessitate comprehensive medical care and close follow-up for longer periods.
2019冠状病毒病（COVID-19）的长期健康后果仍不清楚。之前的大多数试验通过在康复后相对较短的时间内使用综合医学问卷来研究COVID-19后的症状。我们试图检测在严重急性呼吸综合征冠状病毒2（SARS-CoV-2）实时聚合酶链反应（RT-PCR）检测呈阴性后持续超过3个月的潜在病理临床体征和生化残留。
在120名平均年龄为38.29岁、男性比例为55.6%的COVID-19幸存者中，收缩压显著升高（P = 0.001）。COVID-19幸存者的红细胞沉降率（ESR）、C反应蛋白（CRP）、D-二聚体水平较高（P < 0.001）。与COVID-19幸存者血清白蛋白降低相反，丙氨酸转氨酶（ALT）、天冬氨酸转氨酶（AST）、γ-谷氨酰转肽酶（GGT）和碱性磷酸酶（ALP）显著升高（P ≤ 0.001）。COVID-19幸存者的血清脂肪酶、淀粉酶和蛋白尿水平较高（P ≤ 0.001）。回归分析（优势比，95%置信区间）显示，ESR（P = 0.014）、血红蛋白浓度（P = 0.039）、血清脂肪酶（P = 0.018）、血尿素氮（P = 0.003）蛋白尿（P = 0.046）、25（OH）维生素D（P = 0.002）和血清尿酸（P = 0.005）是COVID-19幸存者的显著预测因素（总体预测率为94.8%）。
COVID-19幸存者存在显著的临床和生化改变残留，需要长期的综合医疗护理和密切随访。
