Department of Diagnostic Radiology, Faculty of Applied Medical Science, King Abdulaziz University, Jeddah, Saudi Arabia.
Department of Radiologic Sciences, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Curr Med Imaging. 2023;19(11):1324-1336. doi: 10.2174/1573405619666230208094838.
Shear wave elastography imaging (SWE) is a non-invasive US technique that has been developed to provide quantitative information about tissue elasticity. This technique might be useful in the identification of vascular risk factors. Arterial wall thickness and inner diameter vary with age and disease, which may impact shear wave propagation. The effect of arterial geometry on SWE has not yet been thoroughly investigated. Therefore, this study aimed to investigate the impact of different wall thickness, pulsation and imaging planes on YM estimates, to gain more information about the source of variability associated with SWE.
Poly(vinyl alcohol) cryogel (PVA-c) fabrication has been used for phantom design and construction. The agar-based TMM was used to surround the tubes. The inlet and outlet of the phantom were connected to a programmable gear pump using c-flex tubing to form a closed loop. Image J profiling was used to clarify the anomalies further detected using SWE.
The 4 F/T cycle vessel phantom has shown less YM variability than in the 6 F/T cycle. YM ranged from 8 kPa for a 1 mm thickness tube to 53 kPa for the thickest 6 mm wall thickness for the softer 4 F/T cycle tube. Vessel phantoms embedded in TMM show higher variability than vessel phantoms submerged in water. YM ranged from 32 kPa for a 1 mm thickness tube to 117 kPa for the thickest 6 mm wall thickness for the softer 4 F/T cycle tube.
SWE variability in measurements was higher in phantoms embedded in TMM compared to those submerged in water. It is recommended that combine the transverse and longitudinal imaging planes to provide a better understanding of disease over the full vessel circumference.
剪切波弹性成像（SWE）是一种非侵入性超声技术，旨在提供组织弹性的定量信息。该技术可能有助于识别血管危险因素。动脉壁厚度和内径随年龄和疾病而变化，这可能会影响剪切波的传播。动脉几何形状对 SWE 的影响尚未得到彻底研究。因此，本研究旨在研究不同壁厚、脉动和成像平面对杨氏模量估计值的影响，以获得更多关于与 SWE 相关的可变性来源的信息。
使用聚乙烯醇（PVA）水凝胶（PVA-c）制作仿体设计和构建。使用基于琼脂的 TMM 环绕管。使用 c-flex 管将仿体的入口和出口连接到可编程齿轮泵，形成闭环。使用 Image J 进行轮廓分析，以进一步澄清使用 SWE 检测到的异常。
4 F/T 周期血管仿体的杨氏模量变化小于 6 F/T 周期。杨氏模量范围从最薄 1 毫米壁厚的管的 8kPa 到最厚 6 毫米壁厚的管的 53kPa，对于较软的 4 F/T 周期管。嵌入 TMM 的血管仿体比浸入水中的血管仿体显示出更高的可变性。杨氏模量范围从最薄 1 毫米壁厚的管的 32kPa 到最厚 6 毫米壁厚的管的 117kPa，对于较软的 4 F/T 周期管。
与浸入水中的仿体相比，嵌入 TMM 中的仿体的 SWE 测量值的可变性更高。建议结合横向和纵向成像平面，以更好地了解整个血管周长的疾病。
