Xu Luyao, Li Lingyue, Chen Qianling, Huang Yuebing, Chen Xuebing, Qiao Dongfang
Department of Forensic Pathology, School of Forensic Medicine, Southern Medical University, South Shaitai Road #1023. 510515, Guangzhou, China.
Cell Mol Neurobiol. 2023 Aug;43(6):2415-2436. doi: 10.1007/s10571-023-01323-x. Epub 2023 Feb 8.
Methamphetamine (METH) is an amphetamine-type stimulant that is highly toxic to the central nervous system (CNS). Repeated intake of METH can lead to addiction, which has become a globalized problem, resulting in multiple public health and safety problems. Recently, the non-coding RNA (ncRNA) has been certified to play an essential role in METH addiction through various mechanisms. Herein, we mainly focused on three kinds of ncRNAs including long non-coding RNAs (lncRNAs), microRNAs (miRNAs), and circular RNAs (circRNAs), which are involved in neurotoxicity effects such as cognitive impairment, behavioral abnormalities, and psychiatric disorders due to METH abuse. In addition, differential expression (DE) ncRNAs also suggest that specific responses and sensitivity to METH neurotoxicity exist in different brain regions and cells. We summarized the relationships between the ncRNAs and METH-induced neurotoxicity and psychiatric disturbances, respectively, hoping to provide new perspectives and strategies for the prevention and treatment of METH abuse. Schematic diagram of the non-coding RNAs (ncRNAs) was involved in methamphetamine (METH)-induced neurotoxicity. The ncRNAs were involved in METH-induced blood-brain barrier disruption, neuronal, astrocyte, and microglial damage, and synaptic neurotransmission impairment. The study of ncRNAs is a hot spot in the future to further understand the neurotoxicity of METH and provide more favorable scientific support for clinical diagnosis and innovation of related treatments.
甲基苯丙胺（METH）是一种苯丙胺类兴奋剂，对中枢神经系统（CNS）具有高度毒性。反复摄入METH会导致成瘾，这已成为一个全球化问题，引发了多个公共卫生和安全问题。最近，非编码RNA（ncRNA）已被证实通过多种机制在METH成瘾中发挥重要作用。在此，我们主要关注三种ncRNA，包括长链非编码RNA（lncRNA）、微小RNA（miRNA）和环状RNA（circRNA），它们参与了因METH滥用导致的认知障碍、行为异常和精神障碍等神经毒性效应。此外，差异表达（DE）的ncRNA还表明，不同脑区和细胞对METH神经毒性存在特定反应和敏感性。我们分别总结了ncRNA与METH诱导的神经毒性和精神障碍之间的关系，希望为METH滥用的预防和治疗提供新的视角和策略。非编码RNA（ncRNA）参与甲基苯丙胺（METH）诱导神经毒性的示意图。ncRNA参与了METH诱导的血脑屏障破坏、神经元、星形胶质细胞和小胶质细胞损伤以及突触神经传递障碍。ncRNA的研究是未来进一步了解METH神经毒性并为临床诊断和相关治疗创新提供更有利科学支持的热点。
