Zhang Shuxin, Wang Lirong, Xu Tailin, Zhang Xueji
School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen 518060, China.
ACS Appl Mater Interfaces. 2023 Feb 8. doi: 10.1021/acsami.2c21786.
Diabetic wound healing remains as a serious challenge for medical circles that required continuous monitoring and effective management. Herein, the glucose oxidase/carbon dots@copper-metal-organic framework-based nanofibers (GOx/CDs@MOF NFs) were proposed as a multifunctional wound dressing, aiming to visually monitor wound pH and inhibit bacterial infection. In the diabetic wound microenvironment, the GOx/CDs@MOF NFs could convert endogenous glucose into hydroxyl radial (OH) through the cascade catalytic reaction. In vivo and vitro experimental results confirmed that the GOx/CDs@MOF NFs could efficiently kill bacteria and promote wound healing. Additionally, CDs as a pH fluorescent indicator endowed GOx/CDs@MOF NFs with sensitive and reversible fluorescent sensing behavior to wound pH, and these visual images could also be captured by smartphones and transformed into RGB color mode (red, green, blue) values, allowing for onsite evaluation of the wound status. This multifunctional wound dressing provides a smart and effective solution for diabetic wound management and takes an immeasurable step toward the development of the next generation of digitally visualized wound dressings.
糖尿病伤口愈合仍然是医学界面临的一项严峻挑战，需要持续监测和有效管理。在此，基于葡萄糖氧化酶/碳点@铜金属有机框架的纳米纤维（GOx/CDs@MOF NFs）被提出作为一种多功能伤口敷料，旨在可视化监测伤口pH值并抑制细菌感染。在糖尿病伤口微环境中，GOx/CDs@MOF NFs可通过级联催化反应将内源性葡萄糖转化为羟基自由基（OH）。体内和体外实验结果证实，GOx/CDs@MOF NFs可有效杀灭细菌并促进伤口愈合。此外，碳点作为一种pH荧光指示剂，赋予了GOx/CDs@MOF NFs对伤口pH值敏感且可逆的荧光传感行为，这些可视化图像还可通过智能手机捕获并转换为RGB颜色模式（红、绿、蓝）值，从而实现对伤口状态的现场评估。这种多功能伤口敷料为糖尿病伤口管理提供了一种智能且有效的解决方案，并朝着下一代数字可视化伤口敷料的发展迈出了不可估量的一步。
