Research Unit of Internal Medicine, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.
Forensic Medicine Unit, Finnish Institute for Health and Welfare, Oulu, Finland.
Cardiology. 2023;148(2):134-137. doi: 10.1159/000529501. Epub 2023 Feb 8.
Nonischemic heart disease (NIHD) is the underlying pathology in about 20% of sudden cardiac deaths (SCDs). Psychotropic medication has been reported as a risk factor for SCD among patients with coronary artery disease, but similar information concerning NIHD is scarce.
We evaluated the use of psychotropic medication in victims of SCD due to NIHD and compared it to the general medication use in Finland.
Study population was derived from the Finnish Genetic Study of Arrhythmic Events (Fingesture) (n = 5,869, mean age: 65 ± 12, 79% males; 1,404 victims of SCD due to NIHD, mean age: 57 ± 13, 77% males). All deaths occurred in Northern Finland during 1998-2017. All victims underwent a medicolegal autopsy. Data on use of medication were defined using postmortem toxicology results and patient records. Subjects with neither toxicological analysis nor information of medication use available were excluded. Information on general medication use was derived from Finnish Statistics on Medicines 2018 and presented as defined daily dose/1,000 inhabitants/day.
Psychotropic medication was used by 579 (41%) subjects with NIHD, whereas in the general population, only 12% were estimated to use psychotropics. The results were similar in subgroups of psychotropic medication: 27% versus 2.3% for benzodiazepines, 19% versus 7.5% for antidepressants, and 18% versus 2.2% for antipsychotics.
Use of psychotropic medication is common in victims of SCD due to NIHD compared to the general population.
非缺血性心脏病（NIHD）是约 20%心源性猝死（SCD）的潜在病理原因。有报道称，精神药物是冠心病患者发生 SCD 的危险因素，但关于 NIHD 的类似信息却很少。
我们评估了因 NIHD 导致 SCD 的患者使用精神药物的情况，并将其与芬兰的一般用药情况进行了比较。
研究人群来自芬兰心律失常事件遗传研究（Fingesture）（n=5869，平均年龄 65±12 岁，79%为男性；1404 例因 NIHD 导致的 SCD 患者，平均年龄 57±13 岁，77%为男性）。所有死亡均发生于 1998 年至 2017 年期间的芬兰北部。所有死者均接受了法医尸检。药物使用数据通过死后毒理学结果和病历确定。无毒理学分析或药物使用信息的患者被排除在外。一般用药信息来源于 2018 年芬兰药物统计数据，以每 1000 居民/天的定义日剂量表示。
NIHD 患者中有 579 例（41%）使用了精神药物，而在普通人群中，估计只有 12%使用精神药物。在精神药物亚组中也得到了类似的结果：苯二氮䓬类药物为 27%对 2.3%，抗抑郁药为 19%对 7.5%，抗精神病药为 18%对 2.2%。
与普通人群相比，因 NIHD 导致 SCD 的患者使用精神药物更为常见。
