GoldenBiotech, LLC, 2626 Lavery Court, Unit 307, Newbury Park, CA 91320, USA.
Pharmaceutical Materials Science and Engineering Laboratory, Department of Pharmaceutics, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA.
Int J Pharm. 2023 Mar 25;635:122694. doi: 10.1016/j.ijpharm.2023.122694. Epub 2023 Feb 7.
True density is an important physical property of powdered materials, especially in the context of powder compaction. Currently available methods for true density determination either require a significant amount of materials or are laborious. Hence, a material-sparing and efficient method for true density determination is of value. In this work, we detail a simplified buoyancy-based method capable of fast determination of true density with accuracy comparable to helium pycnometry. This miniaturized method only uses a few milligrams of a powder with data collection process expedited by centrifugation in a laboratory centrifuge. This method can be easily adapted in a laboratory since determination of true density only requires a balance, a micropipette, a laboratory centrifuge, and standard stock liquids of low and high densities. Hence, it is a useful addition to the materials characterization tool kit critical for pharmaceutical formulation development.
真密度是粉末材料的一个重要物理性质，特别是在粉末压实的情况下。目前用于测定真密度的方法要么需要大量的材料，要么很繁琐。因此，一种节省材料且高效的真密度测定方法是有价值的。在这项工作中，我们详细介绍了一种简化的基于浮力的方法，该方法能够快速、准确地测定真密度，其精度可与氦比重瓶法相媲美。这种微型方法仅使用几毫克粉末，通过在实验室离心机中离心加速数据收集过程。由于测定真密度只需要天平、微量移液器、实验室离心机和低、高密度标准储备液，因此该方法可以很容易地在实验室中进行适配。因此，它是药物制剂开发中至关重要的材料特性工具包的有益补充。
