Liu Zhiting, Huang Jiaying, Fang Danqiao, Feng Bohua, Luo Jianxu, Lei Peixuan, Chen Xiaoling, Xie Qingchun, Chen Meiwan, Chen Peihong
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China.
School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, 510006, China.
Mater Today Bio. 2024 Jul 14;27:101153. doi: 10.1016/j.mtbio.2024.101153. eCollection 2024 Aug.
The advantage of low-temperature forming through direct ink writing (DIW) 3D printing is becoming a strategy for the construction of innovative drug delivery systems (DDSs). Optimization of the complex formulation, including factors such as the printing ink, presence of solvents, and potential low mechanical strength, are challenges during process development. This study presents an application of DIW to fabricate water-soluble, high-dose, and sustained-release DDSs. Utilizing poorly compressible metformin hydrochloride as a model drug, a core-shell delivery system was developed, featuring a core composed of 96 % drug powder and 4 % binder, with a shell structure serving as a drug-release barrier. This design aligns with the sustained-release profile of traditional processes, achieving a 25.8 % reduction in volume and enhanced mechanical strength. The strategy facilitates sustained release of high-dose water-soluble formulations for over 12 h, potentially improving patient compliance by reducing formulation size. Process optimization and multi-batch flexibility were also explored in this study. Our findings provide a valuable reference for the development of innovative DDSs and 3D-printed drugs.
通过直接墨水书写（DIW）3D打印进行低温成型的优势正成为构建创新药物递送系统（DDS）的一种策略。在工艺开发过程中，复杂配方的优化面临挑战，这些因素包括打印墨水、溶剂的存在以及潜在的低机械强度等。本研究展示了DIW在制备水溶性、高剂量和缓释DDS方面的应用。以难压缩的盐酸二甲双胍为模型药物，开发了一种核壳递送系统，其核心由96%的药物粉末和4%的粘合剂组成，外壳结构作为药物释放屏障。这种设计与传统工艺的缓释特性相符，体积减少了25.8%，机械强度增强。该策略有助于高剂量水溶性制剂持续释放超过12小时，通过减小制剂尺寸可能提高患者的依从性。本研究还探索了工艺优化和多批次灵活性。我们的研究结果为创新DDS和3D打印药物的开发提供了有价值的参考。
