Division of Pediatric Endocrinology, Children's Healthcare of Atlanta, Emory University School of Medicine, 1400 Tullie Road Northeast, Atlanta, GA 30329, USA.
Division of Endocrinology, Metabolism & Lipids, Emory University School of Medicine, 69 Jesse Hill Jr Drive Southeast, Glenn Building, Room 205, Suite 200, Atlanta, GA 30303, USA.
Endocrinol Metab Clin North Am. 2023 Mar;52(1):27-38. doi: 10.1016/j.ecl.2022.07.003. Epub 2022 Nov 14.
Type 2 diabetes is characterized by progressive decline in pancreatic β-cell function. Studies in adult subjects with newly diagnosed type 2 diabetes have reported that intensive insulin therapy followed by various antihyperglycemic medications can delay β-cell decline. However, this improvement is lost after cessation of therapy. In contrast, youth with type 2 diabetes experience a more rapid loss in β-cell function compared with adults and have loss of β-cell function despite being on insulin and other antihyperglycemic medications. In part one of this two-part review, we discuss studies aiming to achieve diabetes remission with insulin and oral antidiabetic medications.
2 型糖尿病的特征是胰腺β细胞功能进行性下降。在新诊断为 2 型糖尿病的成年患者中进行的研究报告称，强化胰岛素治疗后使用各种降血糖药物可以延缓β细胞的下降。然而，停止治疗后这种改善就会消失。相比之下，与成年人相比，患有 2 型糖尿病的青少年β细胞功能丧失更快，尽管使用胰岛素和其他降血糖药物，β细胞功能仍会丧失。在这篇两部分综述的第一部分中，我们讨论了旨在通过胰岛素和口服降糖药物实现糖尿病缓解的研究。
