Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA; Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.
Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA; Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.
Trends Biochem Sci. 2023 Apr;48(4):315-316. doi: 10.1016/j.tibs.2023.01.007. Epub 2023 Feb 6.
In a recent study, Chaaban and Carter use cryo-electron microscopy (cryo-EM) and an innovative data-processing pipeline to determine the first high-resolution structure of the dynein-dynactin-BICDR1 complex assembled on microtubules. The structure of the complex reveals novel stoichiometry and provides new mechanistic insight into dynein function and mechanism.
在最近的一项研究中，Chaaban 和 Carter 使用冷冻电子显微镜（cryo-EM）和创新的数据处理管道来确定在微管上组装的动力蛋白-动力蛋白激活蛋白-BICDR1 复合物的第一个高分辨率结构。该复合物的结构揭示了新颖的计量关系，并为动力蛋白的功能和机制提供了新的机制见解。
