细胞焦亡与老年退行性疾病。

Pyroptosis and degenerative diseases of the elderly.

机构信息

Department of Otolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, 264000, Shandong, PR China.

Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, Yantai, 264000, Shandong, PR China.

出版信息

Cell Death Dis. 2023 Feb 9;14(2):94. doi: 10.1038/s41419-023-05634-1.

DOI:10.1038/s41419-023-05634-1

PMID:36755014

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9908978/

Abstract

Pyroptosis is a recently described mechanism of programmed cell death mediated by proteins of the gasdermin family. Widely recognized signaling cascades include the classical, non-classical, caspase-3-dependent gasdermin E and caspase-8-dependent gasdermin D pathways. Additional pyroptotic pathways have been subsequently reported. With the rising prevalence of advanced age, the role of pyroptosis in the degenerative diseases of the elderly has attracted increased research attention. This article reviews the primary mechanisms of pyroptosis and summarizes progress in the research of degenerative diseases of the elderly such as presbycusis, age-related macular degeneration, Alzheimer's disease, intervertebral disc degeneration, and osteoarthritis.

摘要

细胞焦亡是一种最近被描述的程序性细胞死亡机制，由gasdermin 家族蛋白介导。广泛认可的信号通路包括经典型、非经典型、依赖 caspase-3 的 gasdermin E 和依赖 caspase-8 的 gasdermin D 途径。随后又报道了其他的细胞焦亡途径。随着年龄的增长，细胞焦亡在老年退行性疾病中的作用引起了越来越多的研究关注。本文综述了细胞焦亡的主要机制，并总结了老年退行性疾病（如老年性聋、年龄相关性黄斑变性、阿尔茨海默病、椎间盘退变和骨关节炎）研究的进展。