National Institute of Pharmaceutical Education and Research, Kolkata, West Bengal, India.
Infectious Diseases and Immunology Division, CSIR-Indian Institute of Chemical Biology, Kolkata, West Bengal, India.
J Med Virol. 2023 Feb;95(2):e28557. doi: 10.1002/jmv.28557.
Dengue is a vector-borne viral disease caused by a Flavivirus whereas the COVID-19 pandemic was caused by a highly contagious virus, SARS-CoV-2 belonging to the family Coronaviridae. However, COVID-19 severity was observably less in dengue-endemic countries and vice versa especially during the active years of the pandemic (2019-2021). We observed that dengue virus (DENV) antibodies (Abs) could cross-react with SARS-CoV-2 spike antigen. This resulted in SARS-CoV-2 false positivity by rapid Ab test kits. DENV Abs binding to SARS-CoV-2 receptor-binding domain (and the reverse scenario), as revealed by docking studies further validated DENV and SARS-CoV-2 cross-reactivity. Finally, SARS-CoV-2 Abs were found to cross-neutralize DENV1 and DENV2 in virus neutralization test (VNT). Abs to other pathogens like Plasmodium were also cross-reactive but non-neutralizing for SARS-CoV-2. Here, we analyze the existing data on SARS-CoV-2 cross-reactivity with other pathogens, especially dengue to assess its impact on health (cross-protection?) and differential sero-diagnosis/surveillance.
登革热是一种由黄病毒引起的虫媒病毒性疾病，而 COVID-19 大流行是由一种高度传染性的病毒引起的，即属于冠状病毒科的 SARS-CoV-2。然而，在登革热流行的国家，COVID-19 的严重程度明显较低，反之亦然，尤其是在大流行的活跃年份（2019-2021 年）。我们观察到登革热病毒（DENV）抗体（Abs）可以与 SARS-CoV-2 刺突抗原发生交叉反应。这导致快速 Ab 检测试剂盒出现 SARS-CoV-2 的假阳性。通过对接研究进一步证实了 DENV 和 SARS-CoV-2 的交叉反应性，揭示了 DENV Abs 与 SARS-CoV-2 受体结合域的结合（以及相反的情况）。最后，在病毒中和试验（VNT）中发现 SARS-CoV-2 Abs 可以交叉中和 DENV1 和 DENV2。像疟原虫这样的其他病原体的 Abs 也与 SARS-CoV-2 发生交叉反应，但不能中和 SARS-CoV-2。在这里，我们分析了 SARS-CoV-2 与其他病原体（尤其是登革热）的交叉反应现有数据，以评估其对健康的影响（交叉保护？）和差异血清诊断/监测。
