Rüdell U, Foth H, Kahl G F
Department of Pharmacology and Toxicology, University of Göttingen, Germany.
Biochem Biophys Res Commun. 1987 Oct 14;148(1):192-8. doi: 10.1016/0006-291x(87)91094-1.
Elimination of nicotine by isolated rat livers was increased eightfold after pretreatment with phenobarbital (PB) as an inducer of cytochrome P-450 while it was only marginally influenced after pretreatment with 5,6-benzoflavone (BF) as an inducer of cytochrome P-448. Initial rates of cotinine formation were enhanced in the same order of magnitude in PB-induced livers. The 14C-nicotine-derived radioactivity excreted into bile within 2 h ranged between 6 -17% of the dose with only 2.7 fold higher values after PB pretreatment compared to controls.
用苯巴比妥（PB）作为细胞色素P - 450的诱导剂进行预处理后，离体大鼠肝脏对尼古丁的消除能力提高了八倍，而用5,6 - 苯并黄酮（BF）作为细胞色素P - 448的诱导剂进行预处理后，尼古丁的消除能力仅受到轻微影响。在PB诱导的肝脏中，可替宁形成的初始速率也以相同的数量级提高。2小时内排泄到胆汁中的14C - 尼古丁衍生放射性占剂量的6 - 17%，与对照组相比，PB预处理后仅高出2.7倍。
