Nakayama H, Nakashima T, Kurogochi Y
Biochim Biophys Acta. 1982 Apr 13;715(2):254-7. doi: 10.1016/0304-4165(82)90367-1.
When rats were pretreated with 3-methylcholanthrene of beta-naphthoflavone, hepatic nicotine oxidase activity per cytochrome P-448 molecule decreased, but the specific activity of the enzyme remained unchanged. After phenobarbital pretreatment, the specific activity of nicotine oxidase increased while the activity of the enzyme per cytochrome P-450 molecule decreased. alpha-Naphthoflavone selectively inhibited the activities of phenobarbital-induced nicotine oxidase and constitutive form(s) of the enzyme. These results show that phenobarbital-induced cytochrome P-450 and constitutive form(s) of the enzyme may be active in hepatic nicotine oxidation.
