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对新西兰的新冠疫情防护框架以及从清零策略过渡的情况进行建模。

Modelling Aotearoa New Zealand's COVID-19 protection framework and the transition away from the elimination strategy.

作者信息

Vattiato Giorgia, Lustig Audrey, Maclaren Oliver, Binny Rachelle N, Hendy Shaun C, Harvey Emily, O'Neale Dion, Plank Michael J

机构信息

School of Mathematics and Statistics, University of Canterbury, Christchurch, New Zealand.

Department of Physics, University of Auckland, Auckland, New Zealand.

出版信息

R Soc Open Sci. 2023 Feb 1;10(2):220766. doi: 10.1098/rsos.220766. eCollection 2023 Feb.

Abstract

For the first 18 months of the COVID-19 pandemic, New Zealand used an elimination strategy to suppress community transmission of SARS-CoV-2 to zero or very low levels. In late 2021, high vaccine coverage enabled the country to transition away from the elimination strategy to a mitigation strategy. However, given negligible levels of immunity from prior infection, this required careful planning and an effective public health response to avoid uncontrolled outbreaks and unmanageable health impacts. Here, we develop an age-structured model for the Delta variant of SARS-CoV-2 including the effects of vaccination, case isolation, contact tracing, border controls and population-wide control measures. We use this model to investigate how epidemic trajectories may respond to different control strategies, and to explore trade-offs between restrictions in the community and restrictions at the border. We find that a low case tolerance strategy, with a quick change to stricter public health measures in response to increasing cases, reduced the health burden by a factor of three relative to a high tolerance strategy, but almost tripled the time spent in national lockdowns. Increasing the number of border arrivals was found to have a negligible effect on health burden once high vaccination rates were achieved and community transmission was widespread.

摘要

在新冠疫情的头18个月里,新西兰采用消除策略将严重急性呼吸综合征冠状病毒2(SARS-CoV-2)的社区传播抑制到零或非常低的水平。2021年末,高疫苗接种覆盖率使该国能够从消除策略过渡到缓解策略。然而,鉴于既往感染产生的免疫力水平可忽略不计,这需要精心规划和有效的公共卫生应对措施,以避免疫情失控和产生无法控制的健康影响。在此,我们针对SARS-CoV-2的德尔塔变异株开发了一个年龄结构模型,其中包括疫苗接种、病例隔离、接触者追踪、边境管控和全人群控制措施的影响。我们使用该模型来研究疫情轨迹如何对不同的控制策略做出反应,并探讨社区限制措施和边境限制措施之间的权衡。我们发现,低病例容忍策略,即随着病例增加迅速转向更严格的公共卫生措施,与高容忍策略相比,可将健康负担降低三分之一,但全国封锁的时间几乎增加两倍。研究发现,一旦实现高疫苗接种率且社区传播广泛,增加边境入境人数对健康负担的影响可忽略不计。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b421/9890088/e48829af49b6/rsos220766f01.jpg

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