Prakasan Aparna Mullangath, Dhas Minolin, Jagathnathkrishna Krishnapillai M, Kumar Aswin, Mathews Susan, Joseph John, Sambasivan Suchetha, James Francis V
Department of Radiation Oncology, Regional Cancer Center, Thiruvananthapuram, Kerala, India.
Department of Biostatistics and Epidemiology, Regional Cancer Centre, Thiruvananthapuram, India.
South Asian J Cancer. 2023 Feb 6;11(4):309-314. doi: 10.1055/s-0041-1735563. eCollection 2022 Oct.
Francis. V. James The study aimed to see the clinical outcome and to identify prognostic factors for survival in patients with carcinoma endometrium. Patients registered at Regional Cancer Centre, Thiruvananthapuram, Kerala, India, with carcinoma endometrium from January 2009 to December 2013 were identified from hospital registry. Data regarding patient demographics, tumor characteristics, treatment schedules, and follow-up were collected using a structured proforma. Survival estimates were generated using the Kaplan-Meier method. Univariate analysis was done using chi-square and Fisher's exact tests. Multivariate analysis using the Cox regression model was performed to determine the impact of prognostic factors on outcome. The statistical analysis was done using SPSS software version 11. The median follow-up of the 686 patients was 95 months (range 3-178 months).There were 432 stage 1 (63%), 100 stage II (14.6%), 108 stage III (15.7%), and 46 stage IV patients (6.7%). The 5-year overall survival was 89.2%. Prognostic factors for survival on univariate analysis were age 60 years or older, nonendometrioid histology, high-grade tumor, cervical stromal involvement, para-aortic node involvement, negative progesterone receptor expression, deep myometrial invasion advanced stage, surgery versus no surgery, serosal involvement, and ovarian and fallopian tube involvement. However, on multivariate analysis, age over 60 years, higher histological grade, advanced stage, and deep myometrial and parametrial invasion were associated with significantly poorer survival. We found that age over 60 years at presentation, higher grade, advanced stage, deep myometrial invasion, and parametrial invasion were associated with poorer survival.
弗朗西斯·V·詹姆斯 本研究旨在观察子宫内膜癌患者的临床结局，并确定其生存的预后因素。
从印度喀拉拉邦特里凡得琅地区癌症中心的医院登记处，识别出2009年1月至2013年12月期间登记的子宫内膜癌患者。使用结构化表格收集有关患者人口统计学、肿瘤特征、治疗方案和随访的数据。采用Kaplan-Meier方法生成生存估计值。使用卡方检验和费舍尔精确检验进行单因素分析。使用Cox回归模型进行多因素分析，以确定预后因素对结局的影响。使用SPSS软件11版进行统计分析。
686例患者的中位随访时间为95个月（范围3 - 178个月）。其中432例为Ⅰ期（63%），100例为Ⅱ期（14.6%），108例为Ⅲ期（15.7%），46例为Ⅳ期患者（6.7%）。5年总生存率为89.2%。单因素分析中生存的预后因素为年龄60岁及以上、非子宫内膜样组织学、高级别肿瘤、宫颈间质受累、腹主动脉旁淋巴结受累、孕激素受体表达阴性、子宫肌层深层浸润、晚期、手术与否、浆膜受累以及卵巢和输卵管受累。然而，多因素分析显示，年龄超过60岁、更高的组织学分级、晚期以及子宫肌层深层和宫旁浸润与生存显著较差相关。
我们发现，就诊时年龄超过60岁、更高分级、晚期、子宫肌层深层浸润和宫旁浸润与较差的生存相关。
