Bond breaking of furan-maleimide adducts a diradical sequential mechanism under an external mechanical force.

Substituted furan-maleimide Diels-Alder adducts are bound by dynamic covalent bonds that make them particularly attractive mechanophores. Thermally activated [4 + 2] retro-Diels-Alder (DA) reactions predominantly proceed a concerted mechanism in the ground electronic state. We show that an asymmetric mechanical force along the anchoring bonds in both the and isomers of proximal dimethyl furan-maleimide adducts favors a sequential pathway. The switching from a concerted to a sequential mechanism occurs at external forces of ≈1 nN. The first bond rupture occurs for a projection of the pulling force on the scissile bond at ≈4.3 nN for the adduct and ≈3.8 nN for the one. The reaction is inhibited for external forces up to ≈3.4 nN for the adduct and 3.6 nN for the one after which it is activated. In the activated region, at 4 nN, the rupture rate of the first bond for the adduct is computed to be ≈3 orders of magnitude larger than for the one in qualitative agreement with recent sonication experiments [Z. Wang and S. L. Craig, , 2019, , 12263-12266]. In the intermediate region of the path between the rupture of the first and the second bond, the lowest singlet state exhibits a diradical character for both adducts and is close in energy to a diradical triplet state. The computed values of spin-orbit coupling along the path are too small for inducing intersystem crossings. These findings open the way for the rational design of DA mechanophores for polymer science and photochemistry.