Zhang Bin, Zhou Wen-Qing, Liu Xu-Teng, Sun Yingying, Zhang Qing-Wei
Department of Chemistry, University of Science and Technology of China Hefei 230026 China
Chem Sci. 2023 Jan 7;14(5):1286-1290. doi: 10.1039/d2sc05841c. eCollection 2023 Feb 1.
Due to the high reactivity of the triple bond, P-stereogenic alkynylphosphines could be easily derivatized, serving as universal building blocks for structurally diverse phosphine compounds. However, the synthesis of alkynylphosphines direct P-C bond formation was unprecedented. Here, we report an efficient method for the synthesis of P-stereogenic alkynylphosphines with high enantioselectivity a Ni-catalyzed asymmetric cross-coupling reaction. The reaction could tolerate a variety of functional groups, affording products that can be converted into useful phosphine derivatives.
由于三键的高反应活性，P-手性炔基膦很容易进行衍生化，可作为结构多样的膦化合物的通用构建单元。然而，通过直接形成P-C键来合成炔基膦此前尚无先例。在此，我们报道了一种通过镍催化的不对称交叉偶联反应高效合成具有高对映选择性的P-手性炔基膦的方法。该反应能够耐受多种官能团，所得到的产物可转化为有用的膦衍生物。
