Sarma Lumbanraja, Helmy Effendi Iman, M Siahaan Andre, E P Bancin Berry, Deri Edianto, Edwin Martin Asroel, Yudha Sudewo
Obstetrics and Gynecology Department, Faculty of Medicine, Universitas Sumatera Utara, Medan, 20136, Indonesia.
Neurosurgery Department, Faculty of Medicine, Universitas Sumatera Utara, Medan, 20136, Indonesia.
Afr J Infect Dis. 2022 Dec 22;17(1):45-54. doi: 10.21010/Ajidv17i1.4. eCollection 2023.
The pandemic caused by SARS-CoV-2 also caused infection in some pregnant women. Some reports say this viral infection can show symptoms of preeclampsia.
We analyzed 25 pregnant women with SARS-CoV-2 infection with 4 patients presenting with symptoms of preeclampsia. we performed routine blood analysis, renal function, liver function, and IHC examination to see the expression of viral proteins in the placenta.
we obtained 4 patients with confirmed SARS-CoV-2 infection by RT-PCR. In these 4 cases, none of the cases showed expression of the SARS-CoV-2 viral protein in the placenta, and all 4 mothers were declared dead after treatment, and 2 babies delivered out of these 4 cases died. In one case we had fetal death in pregnancy while in one case prematurity. 2 babies born to mothers with SARS-CoV-2 infection with preeclampsia were born in good condition. There were no babies infected with SARS-CoV-2.
We conclude that SAR-CoV-2 infection in pregnant women with comorbidities can lead to a poor prognosis for both mother and baby. We cannot yet conclude whether SARS-CoV-2 infection can cause preeclampsia, but SARS-CoV-2 infection can exacerbate preeclampsia symptoms.
由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引起的大流行也导致了一些孕妇感染。一些报告称这种病毒感染可表现为先兆子痫的症状。
我们分析了25例感染SARS-CoV-2的孕妇，其中4例出现先兆子痫症状。我们进行了血常规、肾功能、肝功能及免疫组化检查，以观察病毒蛋白在胎盘中的表达。
我们通过逆转录聚合酶链反应（RT-PCR）确诊了4例SARS-CoV-2感染患者。在这4例病例中，无一例在胎盘中显示SARS-CoV-2病毒蛋白的表达，且所有4位母亲在治疗后均宣告死亡，这4例中的2例所分娩婴儿死亡。其中1例为孕期胎儿死亡，1例为早产。2例感染SARS-CoV-2且伴有先兆子痫的母亲所分娩婴儿出生时状况良好。没有婴儿感染SARS-CoV-2。
我们得出结论，合并症孕妇感染SARS-CoV-2可导致母婴预后不良。我们尚不能得出SARS-CoV-2感染是否会导致先兆子痫的结论，但SARS-CoV-2感染会加重先兆子痫症状。
