Spátola J, Poderoso J J, Wiemeyer J C, Fernández M, Guerreiro R B, Corazza C
Instituto Roffo, University of Buenos Aires, Argentina.
Arzneimittelforschung. 1987 Aug;37(8):965-6.
Lung amoxicillin levels were assessed in tissue obtained from 16 patients who underwent lung resection due to different pulmonary diseases. In this double-blind placebo controlled study patients were allocated to two groups in randomized order; one group received amoxicillin 1000 mg t.i.d. (n = 8) and the other amoxicillin 1000 mg + ambroxol 60 mg t.i.d. (n = 8). A trend towards higher antibiotic lung tissue levels was observed in patients who received the antibiotic together with the mucolytic agent. The ratio pulmonary tissue/serum amoxicillin levels reached a significant difference being higher in the amoxicillin plus ambroxol group than in the other one (0.411 +/- 0.04 vs 0.672 +/- 0.07; p less than 0.01), even if the amoxicillin plasma levels were lower. A possible effect of ambroxol on lung tissue penetration of amoxicillin is suggested and discussed.
对16例因不同肺部疾病接受肺切除术的患者所获组织中的肺部阿莫西林水平进行了评估。在这项双盲、安慰剂对照研究中，患者被随机分为两组；一组接受阿莫西林1000毫克，每日三次（n = 8），另一组接受阿莫西林1000毫克+氨溴索60毫克，每日三次（n = 8）。在接受抗生素与黏液溶解剂联合治疗的患者中，观察到抗生素肺组织水平有升高趋势。肺组织/血清阿莫西林水平之比存在显著差异，阿莫西林加氨溴索组高于另一组（0.411±0.04对0.672±0.07；p<0.01），即便阿莫西林血浆水平较低。文中提出并讨论了氨溴索对阿莫西林肺组织渗透可能产生的影响。
