Wiemeyer J C
Arzneimittelforschung. 1981;31(6):974-6.
Antibiotic levels in bronchopulmonary tissue following oral administration of ampicillin, erythromycin and amoxycillin dosed 50 mg/dg were compared with those obtained by the same treatments n0 mg/dg p.o of trans-4-[(2-amino-3,5-dibromo-benzyl)amino]cyclohexanol (ambroxol, Mucosolvan) in several groups of rats. The addition of ambroxol was correlated with an increase of 234% in the pulmonary average concentration of ampicillin, 27% in that of erythromycin 27% in that of amoxycillin; the statistical evaluation of these differences resulted in less than 0.05 in each case. It may be concluded that ambroxol, through a mechanism still unclear, can increase the antibiotic levels in the lungs of the rat.
在几组大鼠中，比较了口服剂量为50mg/dg的氨苄青霉素、红霉素和阿莫西林后支气管肺组织中的抗生素水平，以及经口给予相同治疗剂量0mg/dg的反式-4-[(2-氨基-3,5-二溴苄基)氨基]环己醇（氨溴索，沐舒坦）后获得的抗生素水平。添加氨溴索后，氨苄青霉素在肺中的平均浓度增加了234%，红霉素增加了27%，阿莫西林增加了27%；对这些差异的统计学评估在每种情况下均小于0.05。可以得出结论，氨溴索通过一种尚不清楚的机制，可以提高大鼠肺中的抗生素水平。
