在胃癌中的表达及临床意义。

Expression and Clinical Significance of in Gastric Cancer.

机构信息

The First School of Clinical Medicine, Lanzhou University, Lanzhou, Gansu 730000, China.

Department of Surgical Oncology, Gansu Provincial Hospital, Lanzhou, Gansu 730000, China.

出版信息

Comb Chem High Throughput Screen. 2023;26(12):2194-2200. doi: 10.2174/1386207326666230209140929.

DOI:10.2174/1386207326666230209140929

PMID:36757044

Abstract

OBJECTIVE

The aim of this research was to investigate the expression of and its potential clinical significance in gastric cancer (GC).

METHODS

In this study, we detected the protein expression levels of in GC tissues and adjacent normal tissues by immunohistochemistry (IHC) and analysed the relationship between the protein expression levels of 2 and clinicopathological parameters of GC patients. Gene Expression Profiling Interactive Analysis (GEPIA) and Kaplan-Meier Plotter were used to verify the diagnostic and prognostic values of . Proteins interacting with were predicted using the SRING database.

RESULTS

Our results showed that the protein expression levels of in GC tissues were lower than those in adjacent normal tissues (all < 0.05), and the protein expression level of was correlated with lymph node metastasis and TNM stage of GC patients (all < 0.05). Aberrant overexpression of was associated with poor prognosis of GC patients. Proteins such as VR1, TRPV1, LHFPL5, STOM, TRPA1 and STOML3 had obvious interactions with PIEZO2 ( = 0.00213).

CONCLUSION

In summary, our current study identified as a promising target for early diagnosis and as a potential prognostic biomarker in GC patients.

摘要

目的

本研究旨在探讨在胃癌（GC）中表达及其潜在的临床意义。

方法

本研究采用免疫组织化学（IHC）检测 GC 组织和相邻正常组织中蛋白的表达水平，并分析蛋白表达水平与 GC 患者临床病理参数之间的关系。基因表达谱交互分析（GEPIA）和 Kaplan-Meier Plotter 用于验证的诊断和预后价值。使用 SRING 数据库预测与相互作用的蛋白。

结果

研究结果表明，GC 组织中蛋白的表达水平低于相邻正常组织（均<0.05），蛋白的表达水平与 GC 患者的淋巴结转移和 TNM 分期相关（均<0.05）。的异常过表达与 GC 患者的不良预后相关。与 PIEZO2 有明显相互作用的蛋白有 VR1、TRPV1、LHFPL5、STOM、TRPA1 和 STOML3（=0.00213）。