From the School of Medicine, California University of Science and Medicine, Colton, CA (Hirpara).
the Department of Plastic Surgery, School of Medicine, University of California San Diego, La Jolla, CA (Clark, Dean, Reid).
J Am Coll Surg. 2023 Jun 1;236(6):1189-1197. doi: 10.1097/XCS.0000000000000648. Epub 2023 Feb 9.
Despite high cost and lack of FDA approval for breast surgery, acellular dermal matrix (ADM) has become commonplace in reconstructive surgery and has been the focus of more than 500 plastic surgery publications since its wide adoption. We hypothesized that ADM-related academic output would correlate with public interest and industry funding.
All PubMed-indexed studies focusing on ADM in 11 plastic surgery journals were included (n = 535). Data on industry funding to the 17 most productive authors were extracted from the Open Payments Database. Google Trends in "breast surgery cost" and related terms were queried. Relationships among publication quantity, author industry funding, and public interest were analyzed by Pearson's correlation and linear regression.
The most published authors produced 8 qualifying publications on average (range 5 to 17), with 80% focused on breast surgery. These individuals grossed a total of $19 million industry dollars overall with $17 million (89%) in nonconsulting compensation from ADM-producing companies (NC-ADM). Individual total compensation and NC-ADM compensation, by quartile, were $194,000/$320,000/$1.25 million and $17,000/$210,000/$1.1 million, respectively. These variables showed strong correlation with individual publication rate with a linear regression coefficient of $110K in NC-ADM per publication (p < 0.01). Authors disclosed funding in a mean ± SD of 65 ± 26% of their work with strong correlation between disclosure and NC-ADM (p < 0.01). Google "breast surgery cost" search volume has grown rapidly in significant correlation with ADM publications (p = 0.02).
This study demonstrates significant correlation between ADM-related publication, industry funding, funding disclosure, and public interest. Education in the potential for such relationships and the importance of objectivity in plastic surgery warrants discussion.
尽管乳房手术的成本高昂且未获得 FDA 批准，脱细胞真皮基质 (ADM) 在重建手术中已变得很普遍，并且自广泛采用以来，已经成为 500 多篇整形外科学术出版物的焦点。我们假设 ADM 相关的学术产出与公众兴趣和行业资金有关。
纳入了 11 种整形外科杂志中所有与 ADM 相关的 PubMed 索引研究（n=535）。从 Open Payments Database 中提取了 17 位最具生产力的作者的行业资助数据。查询了“乳房手术费用”和相关术语的 Google 趋势。通过 Pearson 相关分析和线性回归分析了出版物数量、作者行业资助与公众兴趣之间的关系。
最具影响力的作者平均发表了 8 篇符合条件的论文（范围为 5 至 17 篇），其中 80%的论文集中在乳房手术上。这些人总共从 ADM 生产公司获得了 1900 万美元的行业资金，其中 1700 万美元（89%）是非咨询补偿（NC-ADM）。按四分位数划分，个人总薪酬和 NC-ADM 薪酬分别为 194000 美元/320000 美元/125 万美元和 17000 美元/210000 美元/1100 万美元。这些变量与个人发表率具有很强的相关性，NC-ADM 每发表一篇论文的线性回归系数为 110K（p<0.01）。作者披露的资金占其工作的 65%±26%，披露与 NC-ADM 之间具有很强的相关性（p<0.01）。Google“乳房手术费用”的搜索量与 ADM 出版物呈显著相关（p=0.02）。
本研究表明 ADM 相关出版物、行业资金、资金披露和公众兴趣之间存在显著相关性。需要讨论在整形外科学中存在这种关系的可能性以及客观性的重要性。
