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单纯侧方腰椎间融合的长期耐用性

Long-Term Durability of Stand-Alone Lateral Lumbar Interbody Fusion.

机构信息

Department of Neurological Surgery, Washington University School of Medicine, St. Louis, Missouri, USA.

Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.

出版信息

Neurosurgery. 2023 Jul 1;93(1):60-65. doi: 10.1227/neu.0000000000002371. Epub 2023 Feb 9.

Abstract

BACKGROUND

The long-term durability of stand-alone lateral lumbar interbody fusion (LLIF) remains unknown.

OBJECTIVE

To evaluate whether early patient-reported outcome measures after stand-alone LLIF are sustained on long-term follow-up.

METHODS

One hundred and twenty-six patients who underwent stand-alone LLIF between 2009 and 2017 were included in this study. Patient-reported outcome measures included the Oswestry Disability Index (ODI), EuroQOL-5D (EQ-5D), and visual analog score (VAS) scores. Durable outcomes were defined as scores showing a significant improvement between preoperative and 6-week scores without demonstrating any significant decline at future time points. A repeated measures analysis was conducted using generalized estimating equations (model) to assess the outcome across different postoperative time points, including 6 weeks, 1 year, 2 years, and 5 years.

RESULTS

ODI scores showed durable improvement at 5-year follow-up, with scores improving from 46.9 to 38.5 ( P = .001). Improvements in EQ-5D showed similar durability up to 5 years, improving from 0.48 to 0.65 ( P = .03). VAS scores also demonstrated significant improvements postoperatively that were durable at 2-year follow-up, improving from 7.0 to 4.6 ( P < .0001).

CONCLUSION

Patients undergoing stand-alone LLIF were found to have significant improvements in ODI and EQ-5D at 6-week follow-up that remained durable up to 5 years postoperatively. VAS scores were found to be significantly improved at 6 weeks and up to 2 years postoperatively but failed to reach significance at 5 years. These findings demonstrate that patients undergoing stand-alone LLIF show significant improvement in overall disability after surgery that remains durable at long-term follow-up.

摘要

背景

单纯侧路腰椎间融合术(LLIF)的长期耐久性尚不清楚。

目的

评估单纯 LLIF 后早期患者报告的结局测量指标是否在长期随访中得以维持。

方法

本研究纳入了 2009 年至 2017 年间接受单纯 LLIF 的 126 例患者。患者报告的结局测量包括 Oswestry 功能障碍指数(ODI)、欧洲五维健康量表(EQ-5D)和视觉模拟评分(VAS)。耐用性结果定义为术前和 6 周评分之间存在显著改善,且在未来时间点没有任何显著下降。使用广义估计方程(模型)进行重复测量分析,以评估不同术后时间点的结果,包括 6 周、1 年、2 年和 5 年。

结果

ODI 评分在 5 年随访时显示出持久的改善,从 46.9 分改善至 38.5 分(P=0.001)。EQ-5D 的改善表现出类似的耐久性,从 0.48 提高至 0.65(P=0.03)。VAS 评分也显示出显著的术后改善,在 2 年随访时仍具有耐久性,从 7.0 分改善至 4.6 分(P<0.0001)。

结论

接受单纯 LLIF 的患者在 6 周随访时 ODI 和 EQ-5D 显著改善,术后 5 年仍保持耐久性。VAS 评分在 6 周和 2 年随访时显著改善,但在 5 年随访时未达到显著水平。这些发现表明,接受单纯 LLIF 的患者在手术后整体残疾方面有显著改善,且在长期随访中保持耐久性。

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