根据风险定义 11 至 14 孕周的正常血压。
Definition of normal blood pressure at 11 to 14 weeks' gestation according to risk.
机构信息
Departamento de Ginecología y Obstetricia, Hospital Español.
Departamento de Medicina Fetal, Centro Médico para Atención Fetal Especializada, Hospital Español.
出版信息
Arch Cardiol Mex. 2023;93(1):62-68. doi: 10.24875/ACM.21000247.
OBJECTIVE
To define normal blood pressure at first trimester of pregnancy by performance for pre-eclampsia prediction.
METHOD
A cohort study in singleton pregnancies, according to the competing risks model for pre-eclampsia. Blood pressure was measured according to a standardized method at 11 to 14 weeks' gestation.
RESULTS
Among 797 pregnancies included, there were 40 (5.0%, IC95 3.6; 6.4) deliveries with pre-eclampsia. The systolic, diastolic, and mean arterial blood pressures were respectively of 101(9), 68(8) and 79(8) mmHg in pregnant women who did not develop pre-eclampsia, against 109(10), 75(8) and 86(8) in those who did (p < 0.001, t-test). The areas under the curves were 0.707 (0.637; 0.777), 0.728 (0.661; 0.795), and 0.738 (0.673; 0.803). At a 3% of false positive rate, the cut-off points were 119, 83 and 94 mmHg with predictive values of negative of 95.6%.
CONCLUSIONS
It is feasible to define the normal values for blood pressure in pregnancy on biostatistic and clinical basis.
目的
通过子痫前期预测的表现来定义妊娠早期的正常血压。
方法
这是一项单胎妊娠的队列研究，根据子痫前期的竞争风险模型。血压在 11 至 14 孕周时按照标准化方法测量。
结果
在纳入的 797 例妊娠中，有 40 例（5.0%，95%CI95% 为 3.6%至 6.4%）发生子痫前期。未发生子痫前期的孕妇收缩压、舒张压和平均动脉压分别为 101（9）、68（8）和 79（8）mmHg，而发生子痫前期的孕妇分别为 109（10）、75（8）和 86（8）mmHg（p<0.001，t 检验）。曲线下面积分别为 0.707（0.637；0.777）、0.728（0.661；0.795）和 0.738（0.673；0.803）。在假阳性率为 3%的情况下，截断值分别为 119、83 和 94mmHg，阴性预测值为 95.6%。
结论
基于生物统计学和临床依据来定义妊娠血压正常值是可行的。
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