青少年口腔外生性病变：具有独特临床表现的肌上皮瘤病例报告。

Intraoral exophytic lesion in an adolescent: A case report of myoepithelioma with unique clinical presentation.

机构信息

Faculty of Dentistry, Autonomous University of Sinaloa, Blvd. de las Américas y Av. Universitarios S/N Ciudad Universitaria, Culiacan, Sinaloa C.P. 80010, Mexico; Department of Stomatology, Oral Medicine Unit, Faculty of Dentistry, University of Granada, Granada, Spain.

Head of the Oncopath Laboratory, Pathology of Specialties, Culiacan, Sinaloa, Mexico.

出版信息

J Stomatol Oral Maxillofac Surg. 2023 Sep;124(4):101419. doi: 10.1016/j.jormas.2023.101419. Epub 2023 Feb 8.

DOI:10.1016/j.jormas.2023.101419

PMID:36758900

Abstract

Myoepithelioma is an infrequent benign tumor of the salivary glands, characterized by its composition of myoepithelial cells which can show different shapes and be arranged in various patterns with a well-circumscribed or encapsulated growth. This tumor commonly presents in adults as an asymptomatic swelling of the parotid gland, very rarely in minor salivary glands of children or adolescents, and even rarer in the buccal mucosa, with only six cases reported to date and only one of them presented in an adolescent. We present an additional case of myoepithelioma in the buccal mucosa of a 16-year-old male, with a novel clinical presentation as a non-submucosal exophytic mass. Immunohistochemically, neoplastic cells were positive for CK, S100, p63, and GFAP. The tumour was treated surgically, and the patient showed satisfactory evolution at 1 year of follow-up. The clinical and histopathological characteristics of the reported cases are discussed.

摘要

肌上皮瘤是一种罕见的唾液腺良性肿瘤，其特征为由肌上皮细胞组成，这些细胞具有不同的形态，并以明确的界限或包膜生长方式排列成不同的模式。这种肿瘤常见于成年人，表现为腮腺的无症状肿胀，在儿童或青少年的小唾液腺中非常罕见，在颊黏膜中更为罕见，迄今仅报告了 6 例，其中只有 1 例发生在青少年。我们报告了另 1 例发生在 16 岁男性颊黏膜的肌上皮瘤，其具有非黏膜下外生性肿块的新颖临床表现。免疫组织化学染色显示，肿瘤细胞 CK、S100、p63 和 GFAP 阳性。该肿瘤通过手术治疗，患者在 1 年的随访中表现出满意的结果。讨论了所报告病例的临床和组织病理学特征。