Jiangsu Key Laboratory of TCM Evaluation and Translational Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 211198, PR China.
Jiangsu Key Laboratory of TCM Evaluation and Translational Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 211198, PR China; State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 210009, PR China.
J Ethnopharmacol. 2023 May 10;307:116228. doi: 10.1016/j.jep.2023.116228. Epub 2023 Feb 7.
Maca (Lepidium meyenii) is a medicinal and edible plant that has a long history attention because of its potential to improve fertility and sexual function.
In this study, effects of maca on azoospermia were investigated. The effective components of maca were screened.
The therapeutic action of maca were evaluated in a busulfan-induced azoospermic model.
It was found that maca could alleviate the vacuolation of spermatogenic tubules and testicular lesions, promote the recovery of spermatogenic epithelium, inhibit the proliferation of stromal cells, significantly increase the serum testosterone content, and improve the number and quality of sperm. Maca extract was then divided into polysaccharides, oligosaccharides and small molecules fractions for preliminary screening of efficacy. These results showed that there was no significant difference between the maca polysaccharide fraction and maca extract.
The results were shown that maca can improve non-obstructive azoospermia, the polysaccharide fraction was the active components.
玛咖（Lepidium meyenii）是一种药用和食用植物，由于其改善生育能力和性功能的潜力而受到长期关注。
本研究旨在探讨玛咖对无精子症的作用。筛选玛咖的有效成分。
在白消安诱导的无精子症模型中评价玛咖的治疗作用。
发现玛咖可减轻生精小管的空泡化和睾丸损伤，促进生精上皮的恢复，抑制间质细胞的增殖，显著增加血清睾酮含量，提高精子数量和质量。然后将玛咖提取物分为多糖、寡糖和小分子部分进行疗效初步筛选。结果表明，玛咖多糖部分与玛咖提取物之间无显著性差异。
结果表明玛咖能改善非梗阻性无精子症，多糖部分是其活性成分。
