School of Environmental Science and Engineering, Zhejiang Gongshang University, Hangzhou, 310012, China; Zhejiang Provincial Key Laboratory of Solid Waste Treatment and Recycling, Hangzhou, 310012, China.
School of Environmental Science and Engineering, Zhejiang Gongshang University, Hangzhou, 310012, China.
Environ Pollut. 2023 Apr 1;322:121238. doi: 10.1016/j.envpol.2023.121238. Epub 2023 Feb 7.
As more environmental contaminants emerging, antibiotics and antibiotic resistance genes (ARGs) have caused a substantial increase of antimicrobial resistance (AMR) in environment. Quorum sensing (QS) is a bacterial cell-to-cell communication process that regulates many traits and gene expression, including ARGs and the related genes that contribute to AMR development. Herein, we summarize the role, physiology, and genetic mechanisms of bacterial QS in AMR development in the environment. First, the effect of QS on AMR is introduced. Next, the role of QS in bacterial physiological behaviors that promote AMR development, including membrane permeability, tactic movement, biofilm formation, persister formation, and small colony variants (SCVs), is systematically analyzed. Furthermore, the regulation of QS on the expression of ARGs, generation of reactive oxygen species (ROS), which affects ARGs formation, and horizontal gene transfer (HGT), which accelerates the transmission of ARGs, are discussed to reveal the molecular mechanism for AMR development. This review provides a reference for a better understanding of AMR evolution and novel insights into AMR prevention.
随着越来越多的环境污染物的出现，抗生素和抗生素抗性基因 (ARGs) 导致环境中的抗微生物药物耐药性 (AMR) 大幅增加。群体感应 (QS) 是一种细菌细胞间的通讯过程，调节许多特征和基因表达，包括 ARGs 和有助于 AMR 发展的相关基因。本文总结了细菌 QS 在环境中 AMR 发展中的作用、生理学和遗传机制。首先，介绍了 QS 对 AMR 的影响。接下来，系统分析了 QS 在促进 AMR 发展的细菌生理行为中的作用，包括膜通透性、策略运动、生物膜形成、持久菌形成和小菌落变异体 (SCVs)。此外，还讨论了 QS 对 ARGs 表达、活性氧 (ROS) 产生的调节，ROS 影响 ARGs 的形成，以及水平基因转移 (HGT) ，加速 ARGs 的传播，揭示了 AMR 发展的分子机制。本文的综述为更好地理解 AMR 的进化提供了参考，并为 AMR 的预防提供了新的见解。
