Paediatric Ophthalmology and Strabismus, Moorfields Eye Hospital City Road Campus, London, UK
Paediatric Ophthalmology and Strabismus, Moorfields Eye Hospital City Road Campus, London, UK.
Br J Ophthalmol. 2024 Feb 21;108(3):471-475. doi: 10.1136/bjo-2022-322522.
To validate the East London Retinopathy of Prematurity algorithm (EL-ROP) in a cohort of infants at risk of developing retinopathy of prematurity (ROP).
The EL-ROP algorithm was applied retrospectively to routinely collected data from two tertiary neonatal units in England on infants eligible for ROP screening. The EL-ROP recommendation, to screen or not, was compared with the development of treatment-warranted ROP (TW-ROP) for each infant. The main outcome measures were (1) EL-ROP's sensitivity for predicting the future development of TW-ROP and (2) potential to reduce ROP screening examinations.
Data from 568 infants were included in the trial. The median (IQR) birth weight (g) was 875 (704 - 1103) and gestational age (weeks) was 27.0 (25.4 - 29.0). Maternal ethnicity was black (33%) and non-black (67%). 58(10%) developed TW-ROP and in every case this was predicted by the EL-ROP algorithm. It's sensitivity was 100% (95% CI 94-100%) specificity: 44% (95% CI 39-48%) positive predictive value: 17% (95%CI 16-18%), negative predictive value: 100%.
EL-ROP has been validated in a cohort of infants from two tertiary neonatal units in England. Further validation is required before its clinical usefulness can be assessed.
验证东伦敦早产儿视网膜病变（EL-ROP）算法在一组有发生早产儿视网膜病变（ROP）风险的婴儿中的应用。
EL-ROP 算法被回顾性地应用于英国两个三级新生儿单位常规收集的符合 ROP 筛查条件的婴儿的数据。EL-ROP 的筛查建议（筛查或不筛查）与每个婴儿的治疗性ROP（TW-ROP）的发展进行了比较。主要结局指标是：（1）EL-ROP 预测未来 TW-ROP 发展的敏感性；（2）减少 ROP 筛查检查的潜力。
共有 568 名婴儿的数据纳入了本试验。出生体重（g）中位数（IQR）为 875（704-1103），胎龄（周）为 27.0（25.4-29.0）。母亲的种族是黑人（33%）和非黑人（67%）。58 名（10%）婴儿发展为 TW-ROP，EL-ROP 算法预测了所有这些病例。其敏感性为 100%（95%CI 94-100%），特异性为 44%（95%CI 39-48%），阳性预测值为 17%（95%CI 16-18%），阴性预测值为 100%。
EL-ROP 在英国两个三级新生儿单位的婴儿队列中得到了验证。在评估其临床应用价值之前，还需要进一步验证。
