Cen Yinghuan, Chen Letian, Liu Zihao, Lin Qun, Fang Xiaolin, Yao Herui, Gong Chang
Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 510120, Guangzhou, China.
Breast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 510120, Guangzhou, China.
Cell Death Discov. 2023 Feb 9;9(1):52. doi: 10.1038/s41420-023-01352-x.
Therapy resistance remains a huge challenge for current breast cancer treatments. Exploring molecular mechanisms of therapy resistance might provide therapeutic targets for patients with advanced breast cancer and improve their prognosis. RNA-binding proteins (RBPs) play an important role in regulating therapy resistance. Here we summarize the functions of RBPs, highlight their tremendously important roles in regulating therapy sensitivity and resistance and we also reveal current therapeutic approaches reversing abnormal functions of RBPs in breast cancer.
治疗耐药性仍然是当前乳腺癌治疗面临的巨大挑战。探索治疗耐药性的分子机制可能为晚期乳腺癌患者提供治疗靶点并改善其预后。RNA结合蛋白（RBPs）在调节治疗耐药性中起重要作用。在此，我们总结了RBPs的功能，强调了它们在调节治疗敏感性和耐药性方面极其重要的作用，并且我们还揭示了目前逆转RBPs在乳腺癌中异常功能的治疗方法。
