Department of Medicinal Biotechnology, College of Health Science, Dong-A University, Busan, 49315, Republic of Korea.
Department of Life Science, Chung-Ang University, Seoul, 06974, Republic of Korea.
Genes Genomics. 2024 Aug;46(8):899-907. doi: 10.1007/s13258-024-01530-w. Epub 2024 Jun 7.
RNA-binding proteins (RBPs) perform various biological functions in humans and are associated with several diseases, including cancer. Therefore, RBPs have emerged as novel therapeutic targets. Although recent investigations have shown that RBPs have crucial functions in breast cancer (BC), detailed research is underway to determine the RBPs that are closely related to cancers.
To provide an insight into estrogen receptor (ER) regulation by cold-inducible RNA binding protein (CIRBP) as a novel therapeutic target.
By analyzing the genomic data, we identified a potential RBP in BC. We found that CIRBP is highly correlated with ER function and influences clinical outcomes, such as patient survival and endocrine therapy responsiveness. In addition, CIRBP influences the proliferation of BC cells by directly binding to ER-RNA.
Our results suggest that CIRBP is a novel upstream regulator of ER and that the interplay between CIRBP and ER may be associated with the clinical relevance of BC.
RNA 结合蛋白（RBPs）在人类中具有多种生物学功能，并与包括癌症在内的多种疾病相关。因此，RBPs 已成为新的治疗靶点。尽管最近的研究表明 RBPs 在乳腺癌（BC）中具有重要功能，但仍在进行详细的研究以确定与癌症密切相关的 RBPs。
深入了解冷诱导 RNA 结合蛋白（CIRBP）对雌激素受体（ER）的调节作用，将其作为一种新的治疗靶点。
通过分析基因组数据，我们在 BC 中鉴定出一种潜在的 RBP。我们发现 CIRBP 与 ER 功能高度相关，并影响患者生存和内分泌治疗反应等临床结局。此外，CIRBP 通过直接与 ER-RNA 结合影响 BC 细胞的增殖。
我们的研究结果表明，CIRBP 是 ER 的一个新的上游调节因子，CIRBP 与 ER 之间的相互作用可能与 BC 的临床相关性有关。
