Department of Urology, Huashan Hospital, Fudan University, Shanghai, China.
Fudan Institute of Urology, Huashan Hospital, Fudan University, Shanghai, China.
Br J Cancer. 2023 Apr;128(8):1466-1477. doi: 10.1038/s41416-023-02183-4. Epub 2023 Feb 9.
The clinical significance and immune correlation of CD103 cells in prostate cancer (PCa) remain explored.
In total, 1080 patients with PCa underwent radical prostatectomy from three cohorts were enrolled for retrospective analysis. Tumour microarrays were constructed and fresh tumour samples were analysed by flow cytometry.
High CD103 cell infiltration correlated with reduced biochemical recurrence (BCR)-free survival in PCa. Adjuvant hormone therapy (HT) prolonged the BCR-free survival for high-risk node-negative diseases with CD103 cell abundance. CD103 cell infiltration correlated with less cytotoxic expression and increased infiltration of CD8 and CD4 T cells, M1 macrophages and mast cells in PCa. Intratumoral CD8 T cell was the predominant source of CD103, and the CD103 subset of CD8 T cells was featured with high IL-10, PD-1 and CTLA-4 expression. Tumour-infiltrating CD103 CD8 T cells exerted anti-tumour function when treated with HT ex vivo.
CD103 cell infiltration predicted BCR-free survival and response to adjuvant HT in PCa. CD103 cell infiltration correlated with an enriched but immune-evasive immune landscape. The study supported a model that CD103 expression conferred negative prognostic impact and immunosuppressive function to tumour-infiltrating CD8 T cells, while the CD103 CD8 T cells exhibited a powerful anti-tumour immunity with response to HT.
CD103 细胞在前列腺癌（PCa）中的临床意义和免疫相关性仍在探索中。
总共纳入了三批队列中 1080 名接受根治性前列腺切除术的 PCa 患者进行回顾性分析。构建肿瘤微阵列，并通过流式细胞术分析新鲜肿瘤样本。
高 CD103 细胞浸润与 PCa 患者无生化复发（BCR）生存相关。辅助激素治疗（HT）延长了 CD103 细胞丰度高的高危淋巴结阴性疾病的 BCR 无复发生存期。CD103 细胞浸润与 PCa 中更少的细胞毒性表达以及 CD8 和 CD4 T 细胞、M1 巨噬细胞和肥大细胞的浸润增加相关。肿瘤内 CD8 T 细胞是 CD103 的主要来源，CD103 CD8 T 细胞亚群的特征是高水平的 IL-10、PD-1 和 CTLA-4 表达。肿瘤浸润性 CD103 CD8 T 细胞在接受 HT 体外治疗时发挥抗肿瘤作用。
CD103 细胞浸润预测了 PCa 的 BCR 无复发生存率和对辅助 HT 的反应。CD103 细胞浸润与丰富但免疫逃避的免疫景观相关。该研究支持了一种模型，即 CD103 表达对肿瘤浸润性 CD8 T 细胞赋予了负预后影响和免疫抑制功能，而 CD103 CD8 T 细胞具有强大的抗肿瘤免疫反应，并对 HT 有反应。
