内酰胺的高度区域选择性合成——α,β-不饱和酮、酮酰胺和作为催化剂的DBU的串联反应。
Highly regioselective synthesis of lactams cascade reaction of α,β-unsaturated ketones, ketoamides, and DBU as a catalyst.
作者信息
Qin Xin, Zhang Jinhai, Wang Zhan-Yong, Song Yimei, Yang Yixiao, Zhang Wenhai, Liu Hongxin
机构信息
College of Chemistry and Materials Engineering, Wenzhou University Wenzhou 325035 P. R. China
Institute of New Materials & Industrial Technology, Wenzhou University Wenzhou 325035 P. R. China.
出版信息
RSC Adv. 2023 Feb 6;13(7):4782-4786. doi: 10.1039/d2ra07117g. eCollection 2023 Jan 31.
Herein, the aldol/Michael cascade reaction on the β,γ-positions of α,β-unsaturated ketones with ketoamides to construct bicyclic lactams DBU catalysis has been developed. The substrates were well-tolerated with high regio- and diastereoselectivities in moderate to good yields (32 examples). The control experiments revealed that the hydrogen of the amide was the key factor.
在此，已开发出在α,β-不饱和酮的β,γ位上与酮酰胺进行羟醛/迈克尔串联反应以构建双环内酰胺的DBU催化方法。底物具有良好的耐受性，区域和非对映选择性高，产率中等至良好（32个实例）。对照实验表明，酰胺的氢是关键因素。
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