Salari Paola, Henrard Séverine, O'Mahony Cian, Welsing Paco, Bhadhuri Arjun, Jungo Katharina Tabea, Beck Thomas, O'Mahony Denis, Byrne Stephen, Spinewine Anne, Knol Wilma, Rodondi Nicolas, Schwenkglenks Matthias
Institute of Pharmaceutical Medicine (ECPM), University of Basel, Switzerland.
Louvain Drug Research Institute, Clinical Pharmacy Research Group, UCLouvain, Brussels, Belgium.
Health Serv Insights. 2023 Feb 5;16:11786329231153278. doi: 10.1177/11786329231153278. eCollection 2023.
We identified factors associated with healthcare costs and health-related quality of life (HRQoL) of multimorbid older adults with polypharmacy.
Using data from the OPERAM (OPtimising thERapy to prevent Avoidable hospital admissions in the Multimorbid older people) trial, we described the magnitude and composition of healthcare costs, and time trends of HRQoL, during 1-year after an acute-care hospitalization. We performed a cluster analysis to identify groups with different cost and HRQoL trends. Using multilevel models, we also identified factors associated with costs and HRQoL.
Two months after hospitalization monthly mean costs peaked (CHF 7'124) and HRQoL was highest (0.67). They both decreased thereafter. Age, falls, and comorbidities were associated with higher 1-year costs. Being female and housebound were negatively associated with HRQoL, while moderate alcohol consumption had a positive association. Being independent in daily activities was associated with lower costs and higher HRQoL.
Although only some identified potential influences on costs and HRQoL are modifiable, our observations support the importance of prevention before health deterioration in older people with multimorbid illness and associated polypharmacy.
我们确定了患有多种疾病且用药复杂的老年多病患者的医疗保健成本和健康相关生活质量(HRQoL)的相关因素。
利用OPERAM(优化治疗以预防多病老年人可避免的住院治疗)试验的数据,我们描述了急性护理住院后1年内医疗保健成本的规模和构成以及HRQoL的时间趋势。我们进行了聚类分析,以识别具有不同成本和HRQoL趋势的组。使用多层次模型,我们还确定了与成本和HRQoL相关的因素。
住院后两个月,月平均成本达到峰值(7124瑞士法郎),HRQoL最高(0.67)。此后两者均下降。年龄、跌倒和合并症与1年较高成本相关。女性和居家与HRQoL呈负相关,而适度饮酒呈正相关。日常生活自理与较低成本和较高HRQoL相关。
虽然只有一些已确定的对成本和HRQoL的潜在影响是可改变的,但我们的观察结果支持在患有多种疾病和相关用药复杂的老年人健康恶化之前进行预防的重要性。