Pham Dinh Quoc Huy, Chwastyk Mateusz, Cieplak Marek
Institute of Physics, Polish Academy of Sciences, Warsaw, Poland.
Front Chem. 2023 Jan 25;10:1106599. doi: 10.3389/fchem.2022.1106599. eCollection 2022.
Cellular membraneless organelles are thought to be droplets formed within the two-phase region corresponding to proteinaceous systems endowed with the liquid-liquid transition. However, their metastability requires an additional constraint-they arise in a certain region of density and temperature between the spinodal and binodal lines. Here, we consider the well-studied van der Waals fluid as a test model to work out criteria to determine the location of the spinodal line for situations in which the equation of state is not known. Our molecular dynamics studies indicate that this task can be accomplished by considering the specific heat, the surface tension and characteristics of the molecular clusters, such as the number of component chains and radius of gyration.
细胞无膜细胞器被认为是在与具有液-液转变的蛋白质系统相对应的两相区域内形成的液滴。然而，它们的亚稳定性需要额外的限制条件——它们出现在旋节线和双节线之间密度和温度的特定区域。在这里，我们将研究充分的范德瓦尔斯流体作为一个测试模型，以制定在状态方程未知的情况下确定旋节线位置的标准。我们的分子动力学研究表明，通过考虑比热、表面张力和分子簇的特征，如组成链的数量和回转半径，可以完成这项任务。
