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经导管主动脉瓣置换术(TAVR)后传导阻滞患者使用临时永久起搏器的可行性研究

Feasibility study of temporary permanent pacemaker in patients with conduction block after TAVR.

作者信息

Chang Sanshuai, Liu Xinmin, Lu Zhi-Nan, Yao Jing, Yin Chengqian, Wu Wenhui, Yuan Fei, Luo Taiyang, Liu Ran, Yan Yunfeng, Zhang Qian, Pu Junzhou, Modine Thomas, Piazza Nicolo, Jilaihawi Hasan, Jiang Zhengming, Song Guangyuan

机构信息

Interventional Center of Valvular Heart Disease, Beijing Anzhen Hospital, National Clinical Research Centre for Cardiovascular Diseases, Capital Medical University, Beijing, China.

UMCV, Hôpital Haut Leveque, Centre Hospitalier Universitaire (CHU) de Bordeaux, Bordeaux, France.

出版信息

Front Cardiovasc Med. 2023 Jan 25;10:978394. doi: 10.3389/fcvm.2023.978394. eCollection 2023.

Abstract

BACKGROUND

Limited data exist on the use of temporary permanent pacemaker (TPPM) to reduce unnecessary PPM in patients with high-degree atrioventricular block (HAVB) after transcatheter aortic valve replacement (TAVR).

OBJECTIVES

This study aims to determine the feasibility of TPPM in patients with HAVB after TAVR to provide prolonged pacing as a bridge.

MATERIALS AND METHODS

One hundred and eleven consecutive patients undergoing TAVR were screened from August 2021 to June 2022. Patients with HAVB eligible for PPM were included. TPPM were used in these patients instead of conventional temporary pacing or early PPM. Patients were followed up for 1 month. Holter and pacemaker interrogation were used to determine whether to implant PPM.

RESULTS

Twenty one patients met the inclusion criteria for TPPM, of which 14 patients were third-degree AVB, 1 patient was second-degree AVB, 6 patients were first degree AVB with PR interval > 240 ms and LBBB with QRS duration > 150 ms. TPPM were placed on the 21 patients for 35 ± 7 days. Among 15 patients with HAVB, 26.7% of them ( = 4) recovered to sinus rhythm; 46.7% ( = 7) recovered to sinus rhythm with bundle branch block. The remains of 26.7% patients ( = 4) still had third-degree AVB and received PPM. For patients with first-degree AVB and LBBB, PR interval shortened to < 200 ms in all 6 patients and LBBB recovered in 2 patients. TPPM were successfully removed from all patients and no procedure-related adverse events occurred.

CONCLUSION

TPPM is reliable and safe in the small sample of patients with conduction block after TAVR to provide certain buffer time to distinguish whether a PPM is necessary. Future studies with larger sample are needed for further validation of the current results.

摘要

背景

关于使用临时永久起搏器(TPPM)以减少经导管主动脉瓣置换术(TAVR)后高度房室传导阻滞(HAVB)患者不必要的永久起搏器(PPM)植入的数据有限。

目的

本研究旨在确定TPPM在TAVR后HAVB患者中作为延长起搏桥梁的可行性。

材料与方法

从2021年8月至2022年6月连续筛选111例行TAVR的患者。纳入符合PPM植入标准的HAVB患者。这些患者使用TPPM而非传统临时起搏或早期PPM。对患者进行1个月的随访。使用动态心电图和起搏器程控来确定是否植入PPM。

结果

21例患者符合TPPM纳入标准,其中14例为三度房室传导阻滞,1例为二度房室传导阻滞,6例为一度房室传导阻滞且PR间期>240 ms以及左束支传导阻滞且QRS时限>150 ms。21例患者使用TPPM的时间为35±7天。15例HAVB患者中,26.7%(n = 4)恢复为窦性心律;46.7%(n = 7)恢复为窦性心律伴束支传导阻滞。其余26.7%的患者(n = 4)仍为三度房室传导阻滞并接受了PPM植入。对于一度房室传导阻滞合并左束支传导阻滞的患者,所有6例患者的PR间期均缩短至<200 ms,2例患者的左束支传导阻滞恢复。所有患者的TPPM均成功移除,未发生与手术相关的不良事件。

结论

在TAVR后传导阻滞的小样本患者中,TPPM是可靠且安全的,可为区分是否需要植入PPM提供一定的缓冲时间。需要更大样本的未来研究来进一步验证当前结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8466/9905124/0f5562b7dbc9/fcvm-10-978394-g001.jpg

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