Wang Yuanyuan, Zhang Li, Wu Lu, Cao Ruiyao, Peng Xingwang, Fu Lianguo
Department of Children and Adolescent Health, School of Public Health, Bengbu Medical College, Bengbu, People's Republic of China.
Graduate School of Wannan Medical College, Wuhu, People's Republic of China.
Diabetes Metab Syndr Obes. 2023 Jan 11;16:47-59. doi: 10.2147/DMSO.S391219. eCollection 2023.
Fibronectin type III domain containing protein 5 () gene encodes irisin that regulates adipose tissue metabolism. Peroxide-proliferator-activated receptor γ coactivator 1α () is a powerful promoter of mitochondrial biosynthesis and oxidative metabolism, which plays an important role in inducing heat production and energy consumption of brown fat. expression stimulated an increase in expression of .
The aims of this study were to analyze the association between genetic variants and overweight or obesity in Chinese children and adolescents.
A total of 198 children and adolescents with overweight or obesity and 198 children and adolescents with normal weight were screened according to gender and age 1:1. The healthy eating behaviors, moderate-to-vigorous physical activity time were surveyed using food frequency questionnaire and CLASS questionnaire, respectively. Genotypes of and gene were detected using SNaPshot method.
GT genotype of 5 (rs16835198) increased the risk of overweight or obesity in boys (OR (95% CI): 1.68 (1.00, 2.93)) based on overdominant model; GG genotype of 5 (rs16835198) decreased the risk of overweight or obesity in girls and boys (OR (95% CI): 0.45 (0.21,0.97), 0.45 (0.24, 0.83), respectively) based on dominant model; TT genotype of 5 (rs16835198) increased the risk of overweight or obesity in girls based on recessive model (OR (95% CI): 2.46 (1.19, 5.05)), and based on the additive model (OR (95% CI): 3.82 (1.49, 9.80)). There was significant interaction between 5 (rs16835198) and -1α (rs3755863, rs8192678), healthy eating behaviors, moderate-to-vigorous physical activity time, interaction between (rs8192678) and moderate-to-vigorous physical activity time in the occurrence of overweight or obesity in Chinese children and adolescents.
(rs16835198) played an independent or interactive role with -1α (rs3755863, rs8192678), healthy eating behaviors, moderate-to-vigorous physical activity time in the occurrence of overweight or obesity in Chinese children and adolescents.
含III型纤连蛋白结构域蛋白5（）基因编码鸢尾素，其可调节脂肪组织代谢。过氧化物酶体增殖物激活受体γ共激活因子1α（）是线粒体生物合成和氧化代谢的有力促进因子，在诱导棕色脂肪产热和能量消耗方面发挥重要作用。的表达刺激了的表达增加。
本研究旨在分析中国儿童和青少年基因变异与超重或肥胖之间的关联。
按照性别和年龄1:1比例筛选了198例超重或肥胖儿童和青少年以及198例体重正常的儿童和青少年。分别使用食物频率问卷和CLASS问卷调查健康饮食行为、中等到剧烈身体活动时间。采用SNaPshot方法检测和基因的基因型。
基于超显性模型，5（rs16835198）的GT基因型增加了男孩超重或肥胖的风险（比值比（95%可信区间）：1.68（1.00，2.93））；基于显性模型，5（rs16835198）的GG基因型降低了女孩和男孩超重或肥胖的风险（比值比（95%可信区间）：分别为0.45（0.21，0.97），0.45（0.24，0.83））；基于隐性模型，5（rs16835198）的TT基因型增加了女孩超重或肥胖的风险（比值比（95%可信区间）：2.46（1.19，5.05）），且基于加性模型（比值比（95%可信区间）：3.82（1.49，9.80））。在中国儿童和青少年超重或肥胖的发生中，5（rs16835198）与-1α（rs3755863，rs8192678）、健康饮食行为、中等到剧烈身体活动时间之间存在显著交互作用；（rs8192678）与中等到剧烈身体活动时间之间也存在交互作用。
（rs16835198）在中国儿童和青少年超重或肥胖的发生中与-1α（rs3755863，rs8192678）、健康饮食行为、中等到剧烈身体活动时间发挥独立或交互作用。
