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前房内注射贝伐单抗后脉络膜上腔出血:一例罕见病例报告及文献复习

Suprachoroidal hemorrhage postintracameral bevacizumab injection: An unusual case report and review of literature.

作者信息

Mahalingam Karthikeyan, Angmo Dewang, Neupane Swechya Madhukar, Azad Shorya Vardhan

机构信息

Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

出版信息

Oman J Ophthalmol. 2022 Nov 2;15(3):376-378. doi: 10.4103/ojo.ojo_256_21. eCollection 2022 Sep-Dec.

Abstract

Suprachoroidal hemorrhage (SCH) is a dreaded complication of intraocular surgery. We report a case of a 65-year-old male with left eye primary angle-closure glaucoma and idiopathic elevated episcleral venous pressure with neovascularization of the iris. Due to uncontrolled intraocular pressure even after maximum medical therapy, trabeculectomy with mitomycin C was planned. Preoperative intracameral bevacizumab was given to avoid intraoperative bleeding. Postinjection, localized SCH was noted, which settled spontaneously on conservative management. A combination of ocular and systemic risk factors, such as arteriosclerosis and idiopathic elevated episcleral venous pressure accentuated by intraoperative hypotony during intracameral injection, led to SCH. There are no previous reports of a localized SCH following intracameral bevacizumab.

摘要

脉络膜上腔出血(SCH)是眼内手术的一种可怕并发症。我们报告一例65岁男性患者,患有左眼原发性闭角型青光眼和特发性巩膜静脉压升高伴虹膜新生血管形成。由于即使经过最大程度的药物治疗眼压仍无法控制,计划行丝裂霉素C小梁切除术。术前给予前房内注射贝伐单抗以避免术中出血。注射后,发现局限性脉络膜上腔出血,经保守治疗后自行消退。眼内和全身危险因素的综合作用,如动脉硬化和前房内注射时术中低眼压加剧的特发性巩膜静脉压升高,导致了脉络膜上腔出血。此前尚无关于前房内注射贝伐单抗后发生局限性脉络膜上腔出血的报道。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b37/9905902/064084c2a348/OJO-15-376-g001.jpg

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