在接触石棉的大鼠中诱发腺胃癌的可能性。

Kogan F M, Vanchugova N N, Frasch V N

Research Institute of Labour Hygiene and Professional Disease, Sverdlovsk, USSR.

Br J Ind Med. 1987 Oct;44(10):682-6. doi: 10.1136/oem.44.10.682.

The possibility of glandular stomach cancer being induced was studied in 75 random bred white rats exposed to chrysotile asbestos. A perforated polyethylene capsule containing 100 mg asbestos and filler (beef fat and natural wax mixture 1:1) was introduced in an artificial bag placed on the greater curvature of the stomach. A capsule containing filler only was introduced in a similar way in 40 control rats. In the following 25 months, 18 tumors of the stomach and abdominal cavity were found in the rats treated with asbestos (eight adenomas, two adenocarcinomas, one carcinosarcoma, one forestomach cancer, one intestinal adenocarcinoma, two peritoneal mesotheliomas, and three abdominal lymphoreticulosarcomas.) Among the control rats no such tumors were found. The results of the experiment are discussed in connection with epidemiological data on stomach cancer in asbestos workers.

在75只随机繁殖的白色大鼠中研究了接触温石棉诱发腺胃癌的可能性。将一个装有100毫克石棉和填充剂（牛肉脂肪与天然蜡按1:1混合）的穿孔聚乙烯胶囊放入置于胃大弯处的人造袋中。以类似方式将仅含填充剂的胶囊放入40只对照大鼠体内。在接下来的25个月里，在用石棉处理的大鼠中发现了18个胃和腹腔肿瘤（8个腺瘤、2个腺癌、1个癌肉瘤、1个前胃癌、1个肠腺癌、2个腹膜间皮瘤和3个腹部淋巴网状肉瘤）。在对照大鼠中未发现此类肿瘤。结合石棉工人胃癌的流行病学数据对实验结果进行了讨论。