Pliss G B, Iogannsen M G, Romanov A N, Romanov K P
Vopr Onkol. 1982;28(12):75-81.
The paper discusses the incidence of spontaneous tumors and general morbidity in albino noninbred rats raised at the N. N. Petrov Research Institute of Oncology of the USSR Ministry of Health and used in different chronic experiments. It was found that spontaneous tumors occur, on the average, in 25.7 and malignancies--in 6.2%. Infectious hemorrhagic pneumonia and gastroenteritis (acute capillary toxicosis) are relatively infrequent. The general morbidity patterns in these rats are similar to those in Wistar line, the essential difference being a lower frequency of tumors of the medullar layer of adrenals. Hence, the rats bred at the Institute may be successfully used in various chronic experiments, including those associated with carcinogenic studies.
本文讨论了苏联卫生部N.N.彼得罗夫肿瘤研究所饲养的白化非近交系大鼠的自发肿瘤发病率和一般发病率,这些大鼠用于不同的慢性实验。结果发现,自发肿瘤的平均发生率为25.7%,恶性肿瘤为6.2%。传染性出血性肺炎和肠胃炎(急性毛细血管中毒)相对较少见。这些大鼠的一般发病模式与Wistar品系相似,主要区别在于肾上腺髓质层肿瘤的发生率较低。因此,该研究所饲养的大鼠可成功用于各种慢性实验,包括与致癌研究相关的实验。