Yang Wenbo, Pan Qing, Huang Fuhua, Hu Hongzhi, Shao Zengwu
Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Front Oncol. 2023 Jan 25;12:1105745. doi: 10.3389/fonc.2022.1105745. eCollection 2022.
Bone metastases, as one of the common types of metastatic tumors, have a great impact on the survival period and quality of life of patients. Bone metastases are usually characterized by bone destruction. Skeletal related events caused by bone destruction often lead to pain, pathological fractures and even paralysis. In this review, we provide a detailed explanation of bone metastases from the epidemiology, clinical features, pathogenesis, and recently developed clinical treatment viewpoints. We concluded that the incidence of bone metastases is increasing gradually, with serious clinical symptoms, complex pathogenesis and diverse clinical treatment. Tumor cells, immune cells, osteoblasts/osteoclasts and other cells as well as cytokines and enzymes all play a key role in the pathogenesis of bone metastases. We believe that the future treatment of bone metastases will be diversified and comprehensive. Some advanced technologies, such as nanomedicine, could be used for treatment, but this depends on understanding how disease occurs. With the development of treatment, the survival time and quality of life of patients will be improved.
骨转移作为转移性肿瘤的常见类型之一，对患者的生存期和生活质量有很大影响。骨转移通常以骨质破坏为特征。由骨质破坏引起的骨相关事件常导致疼痛、病理性骨折甚至瘫痪。在本综述中，我们从流行病学、临床特征、发病机制以及最近发展的临床治疗观点等方面对骨转移进行了详细阐释。我们得出结论，骨转移的发病率正在逐渐上升，其临床症状严重，发病机制复杂，临床治疗多样。肿瘤细胞、免疫细胞、成骨细胞/破骨细胞等细胞以及细胞因子和酶在骨转移的发病机制中均起关键作用。我们认为，未来骨转移的治疗将是多样化和综合性的。一些先进技术，如纳米医学，可用于治疗，但这取决于对疾病发生机制的了解。随着治疗的发展，患者的生存时间和生活质量将会得到改善。
