Li Zhaofeng, Zhang Wei, Zhang Zhong, Gao Huile, Qin Yi
Department of Orthopedic, Zhuhai People's Hospital (Zhuhai Hospital Affiliated with Jinan University), Zhuhai, Guangdong, China.
Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan UniversityKey Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced, Chengdu, Sichuan, China.
Expert Opin Drug Deliv. 2022 Oct;19(10):1217-1232. doi: 10.1080/17425247.2022.2093856. Epub 2022 Jul 3.
Bone metastases have gradually been recognized as common metastases that affect patient quality of life and survival due to the increased incidence of primary tumors. However, there is still a lack of effective clinical treatment methods for bone metastases because of their particularity and complexity. Nanomedicine provides a new strategy for the treatment of bone metastases and shows great therapeutic potential. Thus, it is important to review the latest nanomedicine treatments for bone metastases.
This review introduces the mechanistic relationships of bone metastases and summarizes nanotechnology-based treatments of bone metastases according to targeting strategies.
As we start to understand the mechanisms that enable bone metastases, we can better develop nanomedicine treatments. However, many of the mechanisms behind bone metastasis remain unclear. The application of nanomedicine shows promising anti-bone metastasis efficacy and helps to explore the pathogenesis of bone metastases. The optimized construction of nanomedicine according to bone metastatic properties is crucial to ensure the desired anti-bone metastasis efficacy and good biosafety. Therefore, the transition from bench to bedside still requires continued exploration.
由于原发性肿瘤发病率的增加，骨转移已逐渐被认为是影响患者生活质量和生存的常见转移类型。然而，由于骨转移的特殊性和复杂性，目前仍缺乏有效的临床治疗方法。纳米医学为骨转移的治疗提供了一种新策略，并显示出巨大的治疗潜力。因此，综述骨转移的最新纳米医学治疗方法具有重要意义。
本综述介绍了骨转移的机制关系，并根据靶向策略总结了基于纳米技术的骨转移治疗方法。
随着我们开始了解促成骨转移的机制，我们能够更好地开发纳米医学治疗方法。然而，骨转移背后的许多机制仍不清楚。纳米医学的应用显示出有前景的抗骨转移疗效，并有助于探索骨转移的发病机制。根据骨转移特性优化纳米医学的构建对于确保理想的抗骨转移疗效和良好的生物安全性至关重要。因此，从实验室到临床的转化仍需要持续探索。
