Xie Mengqing, Su Chunxia
Department of Oncology, Shanghai Pulmonary Hospital and Thoracic Cancer Institute, School of Medicine, Tongji University, Shanghai, China.
Front Oncol. 2023 Jan 24;12:1006284. doi: 10.3389/fonc.2022.1006284. eCollection 2022.
One of the most frequent distant metastases of lung cancer occurs in the brain. The average natural survival duration for patients with lung cancer who have brain metastases is about 1 to 2 months. Knowledge about brain metastases is currently restricted since they are more difficult to acquire than other metastases. This review begins with an analysis of the immune microenvironment of brain metastases; focuses primarily on the functions of microglia, astrocytes, neurons, and tumor-infiltrating lymphocytes in the microenvironment of brain metastases; and offers an atlas of the immune microenvironment of brain metastases involving significant cells. In an effort to give researchers new research ideas, the study also briefly covers how immunotherapy for non-small cell lung cancer with brain metastases is currently faring.
肺癌最常见的远处转移之一发生在脑部。发生脑转移的肺癌患者的平均自然生存时间约为1至2个月。目前关于脑转移的知识有限，因为获取脑转移相关信息比获取其他转移灶的信息更难。本综述首先分析脑转移的免疫微环境；主要关注小胶质细胞、星形胶质细胞、神经元和肿瘤浸润淋巴细胞在脑转移微环境中的功能；并提供涉及重要细胞的脑转移免疫微环境图谱。为了给研究人员提供新的研究思路，该研究还简要介绍了目前非小细胞肺癌脑转移免疫治疗的进展情况。
