Shetty Bhavya, Fazal Ibrahim, Khan Safiya Fatima, Nambiar Manjusha, D Khadijathul Irfana, Prasad Rohit, Raj Akshata
Department of Periodontics, Faculty of Dental Sciences, Ramaiah University of Applied Sciences, Bangalore, Karnataka - India.
Department of Periodontics, Sri Rajiv Gandhi College of Dental Sciences and Hospital, Bangalore, Karnataka - India.
Drug Target Insights. 2023 Feb 2;17:31-38. doi: 10.33393/dti.2023.2510. eCollection 2023 Jan-Dec.
Cardiovascular diseases (CVDs) are inflammatory diseases of coronary arteries accompanying atheroma formation that can spawn impairment and, in severe cases, death. CVDs are the leading cause of death in the world. In recent decades, investigators have focused their impact on CVD by periodontal disease (PD). PD is a risk factor that can trigger the formation, maturation, and instability of atheroma in the arteries. Two mechanisms have been proposed to explain this relationship: periodontopathic pathogens explicitly invade the circulation or indirectly increase systemic levels of inflammatory mediators. It has been suggested that improvement in disease state has a positive effect on others. This review summarizes evidence from epidemiological studies as well as researches focusing on potential causation channels to deliver a comprehensive representation of the relationship between PD and CVD.
心血管疾病（CVDs）是伴随动脉粥样硬化形成的冠状动脉炎症性疾病，可导致功能损害，严重时可导致死亡。心血管疾病是全球主要的死亡原因。近几十年来，研究人员一直关注牙周病（PD）对心血管疾病的影响。牙周病是一种风险因素，可触发动脉粥样硬化的形成、成熟和不稳定。已提出两种机制来解释这种关系：牙周病原体直接侵入循环系统或间接增加全身炎症介质水平。有人认为疾病状态的改善对其他方面有积极影响。本综述总结了流行病学研究以及关注潜在因果关系途径的研究证据，以全面阐述牙周病与心血管疾病之间的关系。
