Department of Pathogeny Biology, College of Basic Medical Sciences, Jilin University, Changchun 130021, China.
Department of Gynecology and Obstetrics, The Second Hospital of Jilin University, Changchun 130041, China.
Mediators Inflamm. 2023 Jan 31;2023:1481489. doi: 10.1155/2023/1481489. eCollection 2023.
Endometriosis is a common inflammatory illness in which endometrial tissue grows outside the uterine cavity. Immune dysfunction is now widely acknowledged as the primary cause of endometriosis. The immune cell population represented by neutrophils is thought to play an essential role in the etiology, pathophysiology, and associated clinical outcome. There is growing evidence that neutrophils have a role in chronic and aseptic inflammatory diseases, and endometriosis patients have increased levels of neutrophils in plasma, peritoneal fluid, and ectopic endometrium. Here, we sought to review the function of neutrophils in the pathogenesis of endometriosis, with an emphasis on the role of neutrophils in regulating endometrial angiogenesis and the local inflammatory microenvironment.
子宫内膜异位症是一种常见的炎症性疾病，其中子宫内膜组织生长在子宫腔外。免疫功能障碍现在被广泛认为是子宫内膜异位症的主要原因。以中性粒细胞为代表的免疫细胞群被认为在病因、病理生理学和相关临床结局中发挥着重要作用。越来越多的证据表明，中性粒细胞在慢性和无菌性炎症性疾病中发挥作用，子宫内膜异位症患者的血浆、腹腔液和异位子宫内膜中中性粒细胞水平升高。在这里，我们试图综述中性粒细胞在子宫内膜异位症发病机制中的作用，重点探讨中性粒细胞在调节子宫内膜血管生成和局部炎症微环境中的作用。
