Quirk Shae E, Koivumaa-Honkanen Heli, Honkanen Risto J, Mohebbi Mohammadreza, Kavanagh Bianca E, Heikkinen Jeremi, Williams Lana J
School of Medicine, Institute for Mental and Physical Health and Clinical Translation, Deakin University, Geelong, VIC, Australia.
Institute of Clinical Medicine, Psychiatry, University of Eastern Finland, Kuopio, Finland.
Front Psychiatry. 2023 Jan 25;13:1079162. doi: 10.3389/fpsyt.2022.1079162. eCollection 2022.
There is growing evidence of the comorbidity between personality disorder (PD) and musculoskeletal disorders (MSDs). However, there are no systematic reviews including critical appraisal and meta-analyses that identify, evaluate, and synthesize the available evidence on these associations. Therefore, we present here a protocol of the methodology to undertake a systematic review, with the objective to evaluate associations between PD and MSDs in epidemiological population-based studies. A systematic review of observational studies will be conducted. A complete search strategy will be developed in consultation with a health librarian. To identify peer-reviewed literature, the search will be translated for, and implemented in Medline Complete, CINAHL Complete, and PsycINFO the EBSCOhost platform from 1990 to the present. Gray literature will be identified. Studies will be eligible if they examine general population participants aged 15 years and over. Associations of interest are the presence of threshold or positive screen according to the DSM-V/5 (groupings: any, Clusters A, B, C, specific PD) or ICD-10 for PD in relation to arthritis, back/neck conditions, fibromyalgia, osteopenia/osteoporosis, and/or "any" of these MSDs. Data extraction and critical appraisal will be conducted in line with the Joanna Briggs Institute (JBI) guidance for systematic reviews of etiology and risk. The results from all studies will be presented in tables, text, and figures. A descriptive synthesis will present the characteristics of included studies, critical appraisal results, and descriptions of the main findings. Where appropriate, meta-analyses will be performed. If heterogeneity (e.g., = 50%) is detected, subgroup/sensitivity analysis may be used to explore the possible sources. The systematic review does not require ethics approval. The proposed systematic review will strengthen the evidence base on what is known regarding associations between PD and MSDs by identifying, evaluating, and synthesizing the findings of existing observational studies including meta-analyses, where appropriate.
越来越多的证据表明人格障碍（PD）与肌肉骨骼疾病（MSD）之间存在共病现象。然而，目前尚无系统评价（包括批判性评价和荟萃分析）来识别、评估和综合有关这些关联的现有证据。因此，我们在此提出一项进行系统评价的方法方案，目的是评估基于人群的流行病学研究中PD与MSD之间的关联。将对观察性研究进行系统评价。将与健康图书馆员协商制定完整的检索策略。为了识别同行评审文献，检索将针对1990年至今的EBSCOhost平台上的Medline Complete、CINAHL Complete和PsycINFO进行翻译并实施。将识别灰色文献。如果研究对象为15岁及以上的普通人群参与者，则这些研究将符合纳入标准。感兴趣的关联是根据《精神疾病诊断与统计手册》第五版（DSM-V/5，分组：任何类型、A组、B组、C组、特定人格障碍）或国际疾病分类第10版（ICD-10）中人格障碍的阈值或阳性筛查与关节炎、背部/颈部疾病、纤维肌痛、骨质减少/骨质疏松症和/或这些肌肉骨骼疾病中的“任何一种”之间的关联。数据提取和批判性评价将按照乔安娜·布里格斯研究所（JBI）关于病因和风险系统评价的指南进行。所有研究的结果将以表格、文本和图表的形式呈现。描述性综合将展示纳入研究的特征、批判性评价结果以及主要发现的描述。在适当情况下，将进行荟萃分析。如果检测到异质性（例如，I² = 50%），可使用亚组/敏感性分析来探索可能的来源。该系统评价无需伦理批准。拟议的系统评价将通过识别、评估和综合现有观察性研究（包括荟萃分析，如适用）的结果，加强关于PD与MSD之间关联的已知证据基础。
