Joyce Lim Skin & Laser Clinic, Singapore City, Singapore.
J Cosmet Dermatol. 2023 Jun;22(6):1764-1773. doi: 10.1111/jocd.15661. Epub 2023 Feb 10.
The pathophysiology of melasma is multifactorial, resulting in treatment resistance and a high recurrence rate. Recent research suggests that focused ultrasound might treat melasma effectively.
To investigate the efficacy and safety of superficial micro-focused ultrasound with visualization (MFU-V) for melasma in Asians.
Patients (n = 20) with mixed melasma on both cheeks received 2 MFU-V treatments spaced 1 month apart. At monthly visits over 5 months, treatment efficacy and safety were evaluated. Standardized photographs were clinically assessed using the modified Melasma Area and Severity Index (mMASI), and 6-point grading scales for melasma lightening and area of involvement. Patients provided pain, global aesthetic improvement scale (GAIS), and satisfaction assessments.
In 40 cheeks, the mean mMASI score was significantly reduced from 13.2 at baseline to 2.4 at month 4, and 2.8 at month 5. Twenty-nine cheeks (72.5%) showed lightening of melasma at month 4 that persisted until month 5, with improvements up to 75% compared to baseline. Melasma area decreased overall, with sites containing >30% melasma involvement decreasing from 55% to 20% by month 5, and none with 70%-89% involvement. Melasma lightening and area improved visibly in 40% and 20% of cheeks, respectively, as early as 1 month after index MFU-V treatment. Improvements continued after the second treatment and persisted until study closure, correlating with patient GAIS and satisfaction scores. Procedure was well tolerated with only mild-to-moderate pain reported in 92.5% of treatments.
Superficial MFU-V is a safe and effective treatment for melasma.
黄褐斑的病理生理学是多因素的,导致治疗抵抗和高复发率。最近的研究表明,聚焦超声可能有效地治疗黄褐斑。
研究在亚洲人中,浅表微聚焦超声与可视化(MFU-V)治疗黄褐斑的疗效和安全性。
20 例双侧面颊混合型黄褐斑患者接受 2 次 MFU-V 治疗,间隔 1 个月。在 5 个月的每月随访中,评估治疗效果和安全性。使用改良黄褐斑面积和严重程度指数(mMASI)和 6 分黄褐斑变浅和受累面积分级量表对标准照片进行临床评估。患者提供疼痛、整体美学改善量表(GAIS)和满意度评估。
在 40 侧脸颊中,平均 mMASI 评分从基线时的 13.2 显著降低到第 4 个月时的 2.4,第 5 个月时为 2.8。29 侧脸颊(72.5%)在第 4 个月时黄褐斑变浅,这种变浅一直持续到第 5 个月,与基线相比改善了 75%。黄褐斑面积总体减少,包含>30%黄褐斑受累的部位从第 5 个月时的 55%减少到 20%,没有 70%-89%受累的部位。在第 1 次 MFU-V 治疗后 1 个月,40%的脸颊和 20%的脸颊黄褐斑变浅和面积改善明显。第二次治疗后,改善仍在继续,并持续到研究结束,与患者 GAIS 和满意度评分相关。该过程耐受性良好,92.5%的治疗仅报告轻度至中度疼痛。
浅表 MFU-V 是治疗黄褐斑的一种安全有效的方法。