温暖温度触发的发育重编程需要 VIL1 介导的、拟南芥全基因组 H3K27me3 的积累。
Warm temperature-triggered developmental reprogramming requires VIL1-mediated, genome-wide H3K27me3 accumulation in Arabidopsis.
机构信息
Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.
Department of Plant Biology, University of Georgia, Athens, GA 30602, USA.
出版信息
Development. 2023 Mar 1;150(5). doi: 10.1242/dev.201343. Epub 2023 Mar 3.
Changes in ambient temperature immensely affect developmental programs in many species. Plants adapt to high ambient growth temperature in part by vegetative and reproductive developmental reprogramming, known as thermo-morphogenesis. Thermo-morphogenesis is accompanied by massive changes in the transcriptome upon temperature change. Here, we show that transcriptome changes induced by warm ambient temperature require VERNALIZATION INSENSITIVE 3-LIKE 1 (VIL1), a facultative component of the Polycomb repressive complex PRC2, in Arabidopsis. Warm growth temperature elicits genome-wide accumulation of H3K27me3 and VIL1 is necessary for the warm temperature-mediated accumulation of H3K27me3. Consistent with its role as a mediator of thermo-morphogenesis, loss of function of VIL1 results in hypo-responsiveness to warm ambient temperature. Our results show that VIL1 is a major chromatin regulator in responses to high ambient temperature.
环境温度的变化极大地影响了许多物种的发育程序。植物通过营养和生殖发育的重新编程来适应高环境生长温度，这被称为热形态发生。热形态发生伴随着转录组在温度变化时发生大规模变化。在这里，我们表明，温暖环境温度诱导的转录组变化需要 VERNALIZATION INSENSITIVE 3-LIKE 1 (VIL1)，它是多梳抑制复合物 PRC2 的一个可有可无的组成部分，在拟南芥中。温暖的生长温度会引发全基因组范围内的 H3K27me3 积累，而 VIL1 是温暖温度介导的 H3K27me3 积累所必需的。与它作为热形态发生的中介物的作用一致，VIL1 的功能丧失导致对温暖环境温度的低反应性。我们的结果表明，VIL1 是对高环境温度反应的主要染色质调节剂。
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